OVERbone

The REGOS team of the Inserm U1229-RMeS laboratory is pleased to announce the recent funding of the OVERbone proposal as an ANR collaborative research project. OVERbone will be coordinated by Valérie Geoffroy and Angélique Galvani (Inserm U1229, RMeS) and will be carried out with Pierre Weiss (Inserm U1229, RMeS) and in collaboration with Patricia Abellan and Jean Le Bideau (IMN, CNRS U6502). OVERbone aims to investigate a novel mechanism of bone formation based on extracellular vesicles (EVs) secreted by bone cells, that could be used as therapy for bone regeneration. In addition, OVERbone will demonstrate that these EVs are altered during aging either in quantity or in quality and that this alteration contributes to bone aging.

Rémy Cochereau

Semi-permeable vesicles produced by microfluidics to tune the phase behaviour of encapsulated macromolecules

INRAE Nnantes
December 7, 2020, 10h00 - Via Zoom


 
Retirement of Martial Masson
November 30th, 2020
 

Sébastien Grastilleur

Sébastien is post-doctoral researcher. He will work on ANR INDEED


He joined our unit on November 1st 2020
His supervisor is Catherine Le Visage

Baptiste Charbonnier

Baptiste is post-doctoral researcher. He will work on ANR GIJAW


He joined our unit on November 1st 2020
His supervisors are Pierre Corre & Pierre Weiss

Laura Bachir

Laura is a M2 student. She will work on LFC project which aims to develop a new injectable biomaterial


Se joined our unit on October 12th 2020
Her supervisors are Hélène Gautier, Aurélie Billon & Valérie Geoffroy

Launching of the second transversal Inserm program dedicated to Aging (AGEMED 2.0)

The STEP Team is happy to announce that the second transversal Inserm program dedicated to Aging (AGEMED 2.0) will receive a 1.5 M€ grant for the next three years. This research program, coordinated by Eric Gilson (Nice), gathers 11 Research teams from Paris, 2 from Marseille and Grenoble and 1 from Montpellier and Nantes (RMeS STEP team, J.Guicheux and C. Vinatier). The long-term vision of this Inserm program on aging is to ameliorate age-related disorders, improving overall healthspan and reducing public health costs. AGEMED 2.0 will be organized around two main axis. The first axis aims at deciphering the cell senescence code to improve healthspan in chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and osteoarthritis. The second axis deals with integrated approaches to prevent and treat neuroaging disorders in various pre-clinical models. RMeS will receive a financial support for three years to test the efficacy of senolytic compounds in several murine models of osteoarthritis.

Florian Segeron

Florian is a M2 student. He will work on the formulation of a hyalurronic acid hydrogel


He will join our unit on October 12th 2020
His supervisors are Alexis Gaudin & Hélène Gautier

Yoan Moreau

Yoan is an INSERM Technician. He works on SC3M Platform


He joined our unit on October 1st 2020

Mathilde Ambrosino

Mathilde Ambrosino is a PhD student. She works on intra-articular injection of mesenchymal stem cells associated with a cytoprotective boronic hydrogel: assessment in a rabbit model of osteoarthritis.


She joined our unit on October 1st 2020
Her supervisor is Catherine Le Visage

Congratulations to Sarah Beck for her HDR !

Sarah defended her HDR on September 30, 2020 at 2.00 pm (Amphi Ricordeau)

Consortium iPSpine in Nantes

On Jan. 29th and 30th, the consortium iPSpine (Induced pluripotent stem cell-based therapy for spinal regeneration) meeting was held in Nantes (Passage Ste Croix) and organized by RMeS team. This 5-year project falls under the European Union’s Horizon 2020 programme to fund research that improves knowledge, testing, and exploitation platforms that address the future of advanced therapies in Europe. The project is coordinated by Professor Marianna Tryfonidou at Utrecht University.

Prof. Fan Yang

From Zip lining to Lego building: Novel Hydrogels for Stem Cell-based Tissue Regeneration and Disease Modeling

University of Stanford
Jan 17, 2020, 14h30 - Amphi Landais (Dental Faculty)

DEVSTEM

The next DEVSTEM meeting took place on Oct 6, 2020 at 10.00 am in the School of dental Surgery (Amphi Ricordeau). Presentations of Nathan PROVIN & Bastien CIMAROSTI

Emilie Hascoët

Emilie Hascoët is a PhD student and hospitalo-university assistant. She will work on characterization of inflammatory osteoclast precursors in periodontitis


She joined our unit on September 1st 2020
Her supervisor is Alexandra Cloitre

Claire De Fourmestraux

Claire De Fourmestraux is a PhD student and an hospital practitioner in equine surgery. She will work on the interest of resorbable composite biomaterials in osteochondral regeneration.


She joined our unit on September 1st 2020
Her supervisors are Olivier Gauthier & Gwénola Touzot-Jourde

Marie Guicheteau

Marie is a M2 student. She will work on understanding of the multifunctionality of PiT proteins


She joined our unit on September 14th 2020
Her supervisor is Sarah Beck

Estelle Bray

Estelle is a M2 student. She will work on the development of an adhesive hydrogel loaded with nano particles of calcium phosphates with anti-bacterial aim


She will join our unit on October 5th 2020
Her supervisors are Pierre Weiss & Gildas Rethoré

Floriane Kellner

Floriane is a PhD student. She will work on ANR IXBONE project.


She joined our unit on September 1st 2020
Her supervisors are Angélique Galvani & Valérie Geoffroy

Sciences et Avenir - Interview of J. Guicheux

Interview of J. Guicheux in the latest publication of the journal "Sciences et Avenir" as part of an article on "Back pain - The methods that work"

Launching of the INSERM French network : NetwOArk

RMES is happy to announce the launching of the INSERM French network dedicated to peripheral and spine osteoarthritis : NetwOArk. Jerome Guicheux will serve NetwOArk as national coordinator with Francis Berenbaum as a co-coordinator. NetwOArk aims bringing together all the scientific actors involved in osteoarthritis research in order to federate and promote the emergence of high-level scientific works in this field. NetwOArk is created for 4 years and is supported by INSERM, Aviesan and ITMO PMN. NetwOArk is organized around 4 work packages coordinated by Claire Vinatier and Esther Potier (WP 1 pathophysiology), Khorng Ea and Yves-Marie Pers (WP2 disease bio markers), Christelle N’Guyen and Jeremy Sellam (WP3 prevention and treatment) and David Moulin and Emeline Perrier-Groult (WP4 innovation). A first scientific event will be organized in 2020 to gather the French actors involved in Osteoarthritis research. We hope to meet you all to share recent advances in basic, translational and clinical research dedicated to this incurable and disabling disease.

PhD Defense of Pierre Tournier

Congratulations to Pierre who defended his thesis on December 18, 2019 !

Caractérisation biologique d'une pâte osseuse allogénique pour la médecine régénératrice du squelette

Directeur de thèse: P. Weiss - Co-directeur : J. Guicheux - Co-encadrant : A. Gaudin

Charlotte Fosse

Charlotte is in engineering school. She will work on image and data analysis for mapping of intracranial aneurysms


She joined our unit on May 20th 2020
Her supervisor is Florent Autrusseau

Floriane Etienne

Floriane is clinical research assistant. She will work on Discodog and IPSPine projects


She joined our unit on March 2nd 2020
Her supervisors are Marion Fusellier & Johann Clouet

Fatima Fneich

Fatima is post-doctoral researcher. She will work on 3D printing


She joined our unit on March 2nd 2020
Her supervisor is Pierre Weiss

PhD Defense of Leslie Frapin

Congratulations to Leslie who defended her thesis on December 11, 2019 !

Ingénierie tissulaire du disque intervertébral: Développement d'un système à libération séquentielle de facteurs biologiques pour la réparation endogène du disque intervertébral humain

Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux - Co-encadrant : J. Clouet

New funding of BIOREGATE

The STEP team (UMR 1229 INSERM-Nantes University-ONIRIS) is pleased to announce that the project DISCODOG was awarded of BIOREGATE (Région Pays de la Loire) grant (veterinary clinic grant). The project is led by Johann CLOUET and Marion FUSELLIER. This project will be performed in collaboration with the MINT laboratory (INSERM 1066 CNRS 6021) in Angers (Elise LEPELTIER).The two objectives of DISCODOG are to develop a new therapeutic tool to treat discogenic lumbalgia, consisting in miRNA encapsulated in lipid nanocapsules and to validate a new method to detect early signs of disc degeneration in canine patients. After intradiscal injection in clinic dogs, security and efficacy of the treatment will be followed by the mean of orthopedic and neurologic examination as well as by MRI, during 6 months. 120 k€ will be dedicated to the DISCODOG project during 2 years. The project will begin during the first semester of 2020..

J. Guicheux's talk - Rencontres du Lyos (Lyon, 15/11/2019)

Presentation of Jérôme Guicheux at : "Rencontres du LYOS" (Lyon, Nov. 15, 2019) entitled : "Biomatériaux et cellules souches pour la médecine régénératrice des articulations: la route est elle encore longue?"

V. Delplace's talk - Aviesan (Paris, 2/12/2019)

Presentation of Vianney Delplace at : "Journée Aviesan - "3D culture & organoids" (Paris, Dec. 2, 2019) entitled : "Click" hydrogels as innovative tools for 3D cell culture (and more)"

Pauline Le Cam

Pauline is a professional license student. She will work on histological analysis of biomaterials for bone regeneration


She joined our unit on March 2nd 2020
Her supervisors are Hilel Moussi and Julie Le Soeur

Meggane Amiot

Meggane is a M2 student. She will work on characterisation of extracellular vesicles of bone origin


She joined our unit on March 2nd 2020
Her supervisors are Valérie Geoffroy and Angélique Galvani

Mathilde Ambrosino

Mathilde is a M2 student. She will work on stromal mesenchymal cell encapsulation in hydrogels for a potential application in arthrosis


She joined our unit on Feb. 3th 2020
Her supervisors are Catherine Le Visage and Fabien Nativel

Charles Hervochon

Charles is a Pharma student. He will work on mesenchymal stem cell encapsulation


He joined our unit on Feb. 3th 2020
His supervisors are Hélène Gautier and Pierre Weiss

Davy Aubeux

Davy is a PhD student. He will work on resolution of inflammation in clinical situations associated with very common conditions such as dental pulp


He joined our unit on Feb. 3th 2020
His supervisors are Valérie Geoffroy & Alexis Gaudin

Carine Behloul

Carine is a Pharma student. She will work on the development of a composite cement formulation for bone regeneration


She joined our unit on Feb. 3th 2020
Her supervisors are Pierre Weiss and Marie-Michèle Germaini

Charlotte Plard

Charlotte is a M2 student. She will work on mesenchymal stem cells for the treatment of osteoarthritis


She joined our unit on Jan. 13th 2020
Her supervisor is Claire Vinatier

Feras Oyoun

Feras is a M2 student. He will work on REGOMIR Project


He joined our unit on Jan. 6th 2020
His supervisors are Elise Lepeltier (MINT Angers), Angélique Galvani & Valérie Geoffroy

Nathaly Gavira

Nathaly is a M2 student. She will work on comparative anatomy of IVD


She joined our unit on Jan. 2nd 2020
Her supervisors are Johann Clouet, Marion Fusellier & Cyril Decante

Dr. Arnaud Scherberich

Adipose-derived cells for bone regeneration: Generation of bone germs, developmental engineering and use of nanoparticles

University of Bâle
Jan 8, 2020, 11h00 - Amphi Landais (Dental Faculty)

Clément Morin

Clément is a M2 student. He will work on osteoporosis screening via image analysis of CBCT


He joined our unit on Jan. 6th 2020
His supervisor is Florent Autrusseau

Maxime Métayer

Maxime is a M2 student. He will work on IXBONE Project


He will join our unit on Jan. 15th 2020
His supervisors are Angélique Galvani & Pierre Guihard

The DEVSTEM meeting took place on Jan 14, 2020 at 10.00 am in the School of dental Surgery (Amphi Landais). Presentations of Nathan PROVIN & Alexandre BRUNEAU