2021

IFRO New funding by IFRO for HOTSPOT (Heterogeneity of OsteoclasT precursorS in PeriodOnTitis)

The REGOS team of the INSERM UMR_S 1229 RMeS laboratory is pleased to announce that the HOTSPOT project has been funding by the IFRO (Institut Français pour la Recherche Odontologique) 2021 grant. HOTSPOT will be coordinated by Alexandra Cloitre (INSERM UMR_S 1229 RMeS) and will be carried out with Frederic Blanchard (INSERM UMR_S 1238, Phy-OS) with the support of Emilie Hascoët, Julien De Lima and Philippe Lesclous. HOTSPOT aims to identify and characterize inflammatory osteoclast precursors in gingiva from periodontitis patients. These cells may contribute to the alveolar bone loss and, in fine to dental loss associated to periodontitis.

Justine Parisse Justine Parisse

Justine is trainee assistant engineer. She will work on the encapsulation of extracellular vesicles (EVs)


She joined our unit on September 1st 2021
Her supervisors are Pierre Guihard and Pierre Weiss

Olivier G Prof. Olivier Gauthier elected Trustee of the AO Foundation

Professor Olivier Gauthier has been elected "Trustee" of the AO Foundation, a prestigious organization in the world of human and veterinary orthopedics. Congratulations Olivier!

LENA GUYON Lena Guyon

Lena is Engineer. She will work on the BILIPOX and LFC projects


She joined our unit on August 16th 2021
Her supervisors are Alexis Gaudin et Pierre Weiss

V. Delplace Admission of Vianney Delplace for a permanent researcher position at Inserm

RMeS lab is pleased to announce the admission of V. Delplace to the competitive recruitement for a permanent researcher position at Inserm. Bringing in a strong expertise in chemistry and biomedical engineering, he will develop innovative bioprinting technologies for joint-on-a-chip design and novel biomaterial-assisted cell therapy strategies for osteoarthritis treatment. Congratulations Vianney!

FPA Award for J. Guicheux

STEP team is happy to announce that Jerome Guicheux recently received the « Jean Bayle-Lespiteau » Achievement Award from the «Fondation de l’Avenir » (FDA). We are very grateful to FDA board and those who nominated him. STEP team has worked with this health research and innovation dedicated foundation for almost 20 years. This Award is a high honor and also a tribute to the alumni and current members of the STEP team that contribute to make our research a source of hope for patients with joint diseases. A video presenting the activities of the STEP team was filmed on this occasion.

Arnaud Eyraud Arnaud Eyraud

Arnaud is Assistant Engineer. He will be the administrative coordinator and human resources of the unit


He joined our unit on July 1th 2021
His supervisor is Jérôme Guicheux

Marie astrid Marie-Astrid Boutet

Marie-Astrid is post-doc. She will work on the understanding of the pathogenic role of synovial macrophages during osteoarthritis


She joined our unit on February 15th 2021
Her supervisors are Claire Vinatier & Jérôme Guicheux

ATIP AVENIR Selection of M.A. Boutet in program ATIP-Avenir 2021

Marie-Astrid Boutet, currently a postdoc in Claire Vinatier’s group (STEP team), has been selected for the competitive program Inserm/CNRS ATIP-Avenir 2021. Her StratOA group will investigate the diversity of synovial macrophages in osteoarthritis. Congratulations Marie-Astrid !

The DEVSTEM meeting took place on July 6, 2021 in Amphi Landais (Dental Faculty) & via visioconference. Presentations of Jean-baptiste Dupont & Valentin Francois-Campion et Jérome Jullien. Keywords : H2AK119Ub, sperm, early embryogenesis, transcriptomics, epigenetics, polycomb repressive comple

New fundings of SFR

SFR (Société Française de Rhumatologie) has decided to finance 2 RMeS projects : METABONE, led by Dr Sarah Beck-Cormier which aims to understand the role of the PiT2/SLC20A2 protein in bone pathologies associated with metabolic abnormalities & SPHERODISC led by Dr Anne CAMUS. This project aims to characterize the cellular interactions regulating disc tissue homeostasis in a human stem cell-derived organoid model. These investigations will contribute to the discovery of symptom-modifying factors or new therapeutic targets and in the long term to the emergence of innovative treatments that should bring strong benefits to patient with back pain and age-related intervertebral disc diseases.

Maud Maud Viallon

Maud is post-doc. She will work on a multidisciplinary project whose central theme is biopolymers and biomaterials with application in medicine/health.


She joined our unit on February 1, 2021
Her supervisor is Pierre Weiss

Emmaëlle Emmaëlle Carrot

Emmaëlle is a M2 Student. She will work on the bioprinting of an intervertebral disc.


She joined our unit on February 1, 2021
Her supervisor is Catherine Le Visage

James Muncey James Muncey

James is a M2 Student. He will work on the development and biological characterization of a bio-printed synovia model as a basis for the design of mini-joint and in vitro osteoarthritis models


He joined our unit on February 1, 2021
His supervisor is Vianney Delplace

Benoit Bodic Congratulations to Benoit Bodic for his PhD Defense !

Benoit defended his thesis on March 24th, 2021 at 2.00 pm

Amélioration des propriétés anti-arthrosiques des MSC: développement de nouvelles méthodes

Directeur de thèse: J. Guicheux - Co-directeur : F. Djouad (IRMB, Montpellier)

Alban PhD Defense of Alban Fouasson-Chailloux

Alban defended his thesis on April 9th, 2021 at 2.00 pm (salle de conférence de l'hôpital st Jacques)

Arthropathies et Analyse du Mouvement - Arthrose et Arthropathie Hémophilique

Directeur de thèse: Y. Maugars - Co-directeur : F. Rannou

Florent Autrusseau Congratulations to Florent Autrusseau for his HDR !

Florent defended his HDR on February 3rd, 2021 at 2.00 pm

Perception des images numériques, de la sécurité des contenus à l’analyse des images médicales

sport en france Interview of J. Guicheux on the channel "Sport en France"

Jérôme Guicheux participated on February 12 to a program on the channel "Sport en France". He spoke on the programme "Sport, Health & Technology" and answered very general questions about low back pain and research carried out by RMeS

nuit blanche chercheurs Nuit Blanche des Chercheurs (Feb 11th, 2021)

RMeS has participated in the "Nuit Blanche des Chercheurs" by offering a workshop on regenerative medicine. You can replay it on the link : Workshops (from 1h34)

RMes recruits its assistant in administrative management

The candidate will be responsible for performing multi-functional administrative acts. Position profile

The DEVSTEM meeting took place on March 16, 2021 at 10.00 am via visioconference. Presentations of Lily Paillat & Nicolas Vedrenne

regenhu RegenHU's latest 3D bioprinter is in the RMeS lab!

Can't wait to explore the possibilities of this technological gem for all our bioprinting applications!

Prix Johann J. Clouet has received a grant from the "Fondation d'Entreprise Grand Ouest"

We are pleased to announce that Johann CLOUET, PU-PH at RMeS, has received a €5,000 grant from the "Fondation d'Entreprise Grand Ouest" for his NEMESIS project: "Nanoparticles Engineering for MiRNA Encapsulation in Skeletal Innovative Science".

Fellows 2020 P. Weiss becomes a Fellow of Biomaterials Science and Engineering (FBSE)

P. Weiss is really proud to become a Fellow of Biomaterials Science and Engineering (FBSE). He thanks the World Biomaterial organization, the European Society for Biomaterials, the French society Biomat and the colleagues who nominated him. It will be his pleasure to help the community with this new mission..

Congratulations to Giulia Frangi for her PhD Defense !

Giulia defended her thesis on December 15th, 2020 at 2.00 pm

Study of the role of PiT2 at the interface between bone and adipose tissues

Directeur de thèse: S. Beck - Co-directeur : L. Beck

Congratulations to Audrey Smith for her PhD Defense !

Audrey defended her thesis on November 10th, 2020 at 2.00 pm

Cellules stromales mésenchymateuses encapsulées dans des microparticules d'alginate : conception et évaluation de leur potentiel anti-arthrosique après injection intra-articulaire chez le lapin

Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux

Samuel Mandin Samuel Mandin

Samuel is a M2 Student. He will work on a new bioink and a new biopaper (recipient substrate), based on the use of hyaluronic silanised acid, to promote bone regeneration by LAB in situ


He will join our unit on January 25th 2021
His supervisors are Fatima Fneich and Pierre Weiss

Jeremy Brogard Jérémy Brogard

Jérémy is a M2 Student. He will work on 3D bioprinting of mini-joint models


He joined our unit on January 11th 2021
His supervisors are Catherine Le Visage & Pierre Tournier

evendo EVENDO project

The REGOS team of the Inserm U1229-RMeS laboratory is pleased to announce that the EVENDO project won the European Society of Endodontics (ESE) Annual Research Grant 2020. The EVENDO project will be hosted in the research laboratory Inserm U1229 and will be coordinated by Alexis Gaudin with the support of Angelique Galvani, Valerie Geoffroy, Davy Aubeux, Solène Tessier, Pierre Weiss, and Fabienne Pérez. The specific goal of “EVENDO” project is to carry out a detailed characterization of extracellular vesicles derived from primed dental mesenchymal stem cells (pDMSC-EVs) to investigate their involvement as modulators of mesenchymal stem cells anti-inflammatory effects inducing macrophage polarization and to explore whether these pDMSC-EVs may become a valuable tool for promoting dental pulp regeneration.

Paul Humbert Paul Humbert

Paul is post-doctorant. He will work on the project ExcellDisc


He joined our unit on January 4th 2021
His supervisor is Catherine Le Visage

Gabriel Rouau Gabriel Rouau

Gabriel is a M2 Student. He will work on the use of the intravenous route to promote bone regeneration of the irradiated mandible


He joined our unit on January 4th 2021
His supervisors are Florent Espitalier, Valérie Geoffroy & Angélique Galvani

Congratulations to Cyril d'Arros for his PhD Defense !

Cyril defended his thesis on October 2nd, 2020

Développement d'un substitut osseux hautement malléable et cohésif, un nouveau concept de matrice pour la régénération osseuse

Directeur de thèse: O. Malard - Co-directeur : G. Daculsi

Ségolène Ségolène Reiss

Ségolène is a M2 Student. She will work on the assessment of bone neoformation in Vivo of 3D printed implants


She joined our unit on January 4th 2021
Her supervisors are Arnaud Paré & Pierre Weiss

Maeva Maëva Dutilleul

Maëva is an assistant engineer. She will work on histology platform


She joined our unit on January 4th 2021
Her supervisors are Pierre Weiss & Julie Lesoeur

Julie Julie Warin

Julie is a M2 Student. She will work on development and regeneration of the intervertebral disc


She joined our unit on January 4th 2021
Her supervisor is Anne Camus

2020

OVERbone

The REGOS team of the Inserm U1229-RMeS laboratory is pleased to announce the recent funding of the OVERbone proposal as an ANR collaborative research project. OVERbone will be coordinated by Valérie Geoffroy and Angélique Galvani (Inserm U1229, RMeS) and will be carried out with Pierre Weiss (Inserm U1229, RMeS) and in collaboration with Patricia Abellan and Jean Le Bideau (IMN, CNRS U6502). OVERbone aims to investigate a novel mechanism of bone formation based on extracellular vesicles (EVs) secreted by bone cells, that could be used as therapy for bone regeneration. In addition, OVERbone will demonstrate that these EVs are altered during aging either in quantity or in quality and that this alteration contributes to bone aging.

Sébastien Grastilleur

Sébastien is post-doctoral researcher. He will work on ANR INDEED


He joined our unit on November 1st 2020
His supervisor is Catherine Le Visage

Baptiste Charbonnier

Baptiste is post-doctoral researcher. He will work on ANR GIJAW


He joined our unit on November 1st 2020
His supervisors are Pierre Corre & Pierre Weiss

Laura Bachir

Laura is a M2 student. She will work on LFC project which aims to develop a new injectable biomaterial


Se joined our unit on October 12th 2020
Her supervisors are Hélène Gautier, Aurélie Billon & Valérie Geoffroy

Launching of the second transversal Inserm program dedicated to Aging (AGEMED 2.0)

The STEP Team is happy to announce that the second transversal Inserm program dedicated to Aging (AGEMED 2.0) will receive a 1.5 M€ grant for the next three years. This research program, coordinated by Eric Gilson (Nice), gathers 11 Research teams from Paris, 2 from Marseille and Grenoble and 1 from Montpellier and Nantes (RMeS STEP team, J.Guicheux and C. Vinatier). The long-term vision of this Inserm program on aging is to ameliorate age-related disorders, improving overall healthspan and reducing public health costs. AGEMED 2.0 will be organized around two main axis. The first axis aims at deciphering the cell senescence code to improve healthspan in chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and osteoarthritis. The second axis deals with integrated approaches to prevent and treat neuroaging disorders in various pre-clinical models. RMeS will receive a financial support for three years to test the efficacy of senolytic compounds in several murine models of osteoarthritis.

Florian Segeron

Florian is a M2 student. He will work on the formulation of a hyalurronic acid hydrogel


He will join our unit on October 12th 2020
His supervisors are Alexis Gaudin & Hélène Gautier

Yoan Moreau

Yoan is an INSERM Technician. He works on SC3M Platform


He joined our unit on October 1st 2020

Mathilde Ambrosino

Mathilde Ambrosino is a PhD student. She works on intra-articular injection of mesenchymal stem cells associated with a cytoprotective boronic hydrogel: assessment in a rabbit model of osteoarthritis.


She joined our unit on October 1st 2020
Her supervisor is Catherine Le Visage

Congratulations to Sarah Beck for her HDR !

Sarah defended her HDR on September 30, 2020 at 2.00 pm (Amphi Ricordeau)

Consortium iPSpine in Nantes

On Jan. 29th and 30th, the consortium iPSpine (Induced pluripotent stem cell-based therapy for spinal regeneration) meeting was held in Nantes (Passage Ste Croix) and organized by RMeS team. This 5-year project falls under the European Union’s Horizon 2020 programme to fund research that improves knowledge, testing, and exploitation platforms that address the future of advanced therapies in Europe. The project is coordinated by Professor Marianna Tryfonidou at Utrecht University.

Prof. Fan Yang

From Zip lining to Lego building: Novel Hydrogels for Stem Cell-based Tissue Regeneration and Disease Modeling

University of Stanford
Jan 17, 2020, 14h30 - Amphi Landais (Dental Faculty)

DEVSTEM

The next DEVSTEM meeting took place on Oct 6, 2020 at 10.00 am in the School of dental Surgery (Amphi Ricordeau). Presentations of Nathan PROVIN & Bastien CIMAROSTI

Emilie Hascoët

Emilie Hascoët is a PhD student and hospitalo-university assistant. She will work on characterization of inflammatory osteoclast precursors in periodontitis


She joined our unit on September 1st 2020
Her supervisor is Alexandra Cloitre

Claire De Fourmestraux

Claire De Fourmestraux is a PhD student and an hospital practitioner in equine surgery. She will work on the interest of resorbable composite biomaterials in osteochondral regeneration.


She joined our unit on September 1st 2020
Her supervisors are Olivier Gauthier & Gwénola Touzot-Jourde

Marie Guicheteau

Marie is a M2 student. She will work on understanding of the multifunctionality of PiT proteins


She joined our unit on September 14th 2020
Her supervisor is Sarah Beck

Estelle Bray

Estelle is a M2 student. She will work on the development of an adhesive hydrogel loaded with nano particles of calcium phosphates with anti-bacterial aim


She will join our unit on October 5th 2020
Her supervisors are Pierre Weiss & Gildas Rethoré

Floriane Kellner

Floriane is a PhD student. She will work on ANR IXBONE project.


She joined our unit on September 1st 2020
Her supervisors are Angélique Galvani & Valérie Geoffroy

Sciences et Avenir - Interview of J. Guicheux

Interview of J. Guicheux in the latest publication of the journal "Sciences et Avenir" as part of an article on "Back pain - The methods that work"

Launching of the INSERM French network : NetwOArk

RMES is happy to announce the launching of the INSERM French network dedicated to peripheral and spine osteoarthritis : NetwOArk. Jerome Guicheux will serve NetwOArk as national coordinator with Francis Berenbaum as a co-coordinator. NetwOArk aims bringing together all the scientific actors involved in osteoarthritis research in order to federate and promote the emergence of high-level scientific works in this field. NetwOArk is created for 4 years and is supported by INSERM, Aviesan and ITMO PMN. NetwOArk is organized around 4 work packages coordinated by Claire Vinatier and Esther Potier (WP 1 pathophysiology), Khorng Ea and Yves-Marie Pers (WP2 disease bio markers), Christelle N’Guyen and Jeremy Sellam (WP3 prevention and treatment) and David Moulin and Emeline Perrier-Groult (WP4 innovation). A first scientific event will be organized in 2020 to gather the French actors involved in Osteoarthritis research. We hope to meet you all to share recent advances in basic, translational and clinical research dedicated to this incurable and disabling disease.

PhD Defense of Pierre Tournier

Congratulations to Pierre who defended his thesis on December 18, 2019 !

Caractérisation biologique d'une pâte osseuse allogénique pour la médecine régénératrice du squelette

Directeur de thèse: P. Weiss - Co-directeur : J. Guicheux - Co-encadrant : A. Gaudin

Charlotte Fosse

Charlotte is in engineering school. She will work on image and data analysis for mapping of intracranial aneurysms


She joined our unit on May 20th 2020
Her supervisor is Florent Autrusseau

Floriane Etienne

Floriane is clinical research assistant. She will work on Discodog and IPSPine projects


She joined our unit on March 2nd 2020
Her supervisors are Marion Fusellier & Johann Clouet

Fatima Fneich

Fatima is post-doctoral researcher. She will work on 3D printing


She joined our unit on March 2nd 2020
Her supervisor is Pierre Weiss

PhD Defense of Leslie Frapin

Congratulations to Leslie who defended her thesis on December 11, 2019 !

Ingénierie tissulaire du disque intervertébral: Développement d'un système à libération séquentielle de facteurs biologiques pour la réparation endogène du disque intervertébral humain

Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux - Co-encadrant : J. Clouet

New funding of BIOREGATE

The STEP team (UMR 1229 INSERM-Nantes University-ONIRIS) is pleased to announce that the project DISCODOG was awarded of BIOREGATE (Région Pays de la Loire) grant (veterinary clinic grant). The project is led by Johann CLOUET and Marion FUSELLIER. This project will be performed in collaboration with the MINT laboratory (INSERM 1066 CNRS 6021) in Angers (Elise LEPELTIER).The two objectives of DISCODOG are to develop a new therapeutic tool to treat discogenic lumbalgia, consisting in miRNA encapsulated in lipid nanocapsules and to validate a new method to detect early signs of disc degeneration in canine patients. After intradiscal injection in clinic dogs, security and efficacy of the treatment will be followed by the mean of orthopedic and neurologic examination as well as by MRI, during 6 months. 120 k€ will be dedicated to the DISCODOG project during 2 years. The project will begin during the first semester of 2020..

J. Guicheux's talk - Rencontres du Lyos (Lyon, 15/11/2019)

Presentation of Jérôme Guicheux at : "Rencontres du LYOS" (Lyon, Nov. 15, 2019) entitled : "Biomatériaux et cellules souches pour la médecine régénératrice des articulations: la route est elle encore longue?"

V. Delplace's talk - Aviesan (Paris, 2/12/2019)

Presentation of Vianney Delplace at : "Journée Aviesan - "3D culture & organoids" (Paris, Dec. 2, 2019) entitled : "Click" hydrogels as innovative tools for 3D cell culture (and more)"

Pauline Le Cam

Pauline is a professional license student. She will work on histological analysis of biomaterials for bone regeneration


She joined our unit on March 2nd 2020
Her supervisors are Hilel Moussi and Julie Le Soeur

Meggane Amiot

Meggane is a M2 student. She will work on characterisation of extracellular vesicles of bone origin


She joined our unit on March 2nd 2020
Her supervisors are Valérie Geoffroy and Angélique Galvani

Mathilde Ambrosino

Mathilde is a M2 student. She will work on stromal mesenchymal cell encapsulation in hydrogels for a potential application in arthrosis


She joined our unit on Feb. 3th 2020
Her supervisors are Catherine Le Visage and Fabien Nativel

Charles Hervochon

Charles is a Pharma student. He will work on mesenchymal stem cell encapsulation


He joined our unit on Feb. 3th 2020
His supervisors are Hélène Gautier and Pierre Weiss

Davy Aubeux

Davy is a PhD student. He will work on resolution of inflammation in clinical situations associated with very common conditions such as dental pulp


He joined our unit on Feb. 3th 2020
His supervisors are Valérie Geoffroy & Alexis Gaudin

Carine Behloul

Carine is a Pharma student. She will work on the development of a composite cement formulation for bone regeneration


She joined our unit on Feb. 3th 2020
Her supervisors are Pierre Weiss and Marie-Michèle Germaini

Charlotte Plard

Charlotte is a M2 student. She will work on mesenchymal stem cells for the treatment of osteoarthritis


She joined our unit on Jan. 13th 2020
Her supervisor is Claire Vinatier

Feras Oyoun

Feras is a M2 student. He will work on REGOMIR Project


He joined our unit on Jan. 6th 2020
His supervisors are Elise Lepeltier (MINT Angers), Angélique Galvani & Valérie Geoffroy

Nathaly Gavira

Nathaly is a M2 student. She will work on comparative anatomy of IVD


She joined our unit on Jan. 2nd 2020
Her supervisors are Johann Clouet, Marion Fusellier & Cyril Decante

Dr. Arnaud Scherberich

Adipose-derived cells for bone regeneration: Generation of bone germs, developmental engineering and use of nanoparticles

University of Bâle
Jan 8, 2020, 11h00 - Amphi Landais (Dental Faculty)

Clément Morin

Clément is a M2 student. He will work on osteoporosis screening via image analysis of CBCT


He joined our unit on Jan. 6th 2020
His supervisor is Florent Autrusseau

Maxime Métayer

Maxime is a M2 student. He will work on IXBONE Project


He will join our unit on Jan. 15th 2020
His supervisors are Angélique Galvani & Pierre Guihard

The next DEVSTEM meeting took place on Jan 14, 2020 at 10.00 am in the School of dental Surgery (Amphi Landais). Presentations of Nathan PROVIN & Alexandre BRUNEAU

New funding of ANR 2019

The STEP team of the INSERM U1229-RMeS laboratory is pleased to announce the recent funding of the EXCELLDISC proposal as an ANR collaborative research project. EXCELLDISC will be coordinated by Catherine Le Visage (INSERM U1229, RMeS) and will be carried out in collaboration with Florence Gazeau (MSC CNRS 7087) and Grégory Lavieu (U932, Institut Curie). EXCELLDISC will investigate whether MSC-derived extracellular vesicles (EVs) could contribute to slow down, stop or reverse intervertebral disc degeneration. .

Agathe Louisy

Agathe is a M2 student. She will work on the potential involvement of IL-33 in the bone resorption associated to periodontitis.


She joined our unit on Nov. 11th 2019
Her supervisor is Alexandra Cloitre

PhD Defense of Arnaud Paré

Arnaud defended his thesis on July 11, 2019, at 14.00 pm (Amphi Ricordeau)

Rôle de l'apport du dioxygène dans la régénération osseuse en zone ischémique: application aux défauts osseux mandibulaires interrupteurs

Directeur de thèse: P. Corre - Co-directeur : Olivier Gauthier

Nathan Lagneau
Nathan is a PhD student. He will develop a new hydrogel-assisted cell therapy for the treatment of peripheral joint osteoarthritis.


He joined our lab on Oct. 1st 2019
He is supervised by Dr V. Delplace & Prof Y. Maugars

Mélina Georget

Mélina is a PhD student. She will study the role of senescence in osteoarthritis and explore new anti-aging strategies to treat osteoarthritis.


She joined our unit on Sept. 9th 2019
Her supervisors are Dr C Vinatier and Pr G Grimandi


  Nicolas Védrenne
Nicolas is post-doctoral researcher
He will work on Notochordal differentiation and stem cell-based therapy for intervertebral disc degeneration (H2020 iPSpine project)

He joined our unit on March 11th 2019
His supervisor is Anne Camus

New funding of ANR JCJC 2019

The REGOS team of the INSERM U1229-RMeS laboratory is pleased to announce the success of the BILIPOX project in ANR JCJC 2019. The laboratory will receive a grant of 305k€ for 3 years to hire dedicated staff (Engineer and technician). The BILIPOX project will be coordinated by Alexis Gaudin and will be carried out in collaboration with Christophe Blanquart (CRCINA, INSERM UMR 1232), Philippe Legrand (UMR 5253 CNRS- UM-ENSCM), Jeff Johnson (Cayman Chemical Company) and Stéphane Simon (University Paris Diderot (Paris VII). The specific goal of this project is to evaluate the potential benefits of a new biphasic microgel as lipoxin A4 (LXA4) delivery system for tissue engineering (pulp and periodontal tissue). The results of BILIPOX may provide a better understanding of microgels/macrophage interaction. This would be an important milestone for hydrogels modular strategy that open a new way to design and to multi-functionalize drug delivery systems.

DEVSTEM 2019

The next DEVSTEM meeting will take place on Sept 24, 2019 at 10.00 am in the School of dental Surgery (Amphi Landais). Presentations of Méryl ROUDAUT, Nathan PROVIN & Matthieu GIRAUD

Hassan Kaafarani

Hassan is a M2 student.
He will work on REGOMIR project

He joined our unit on Feb. 20th 2019
His supervisor is Valérie Geoffroy

Pierre-Guillaume Piriou

Pierre-Guillaume is a M2 student.
He will work on the evaluation of the biomechanical characteristics of coronary stents and their performance in simple model and bifurcation model.

He joined our unit on Jan. 28th 2019
His supervisors are Thierry Rouillon & Fabienne Jordana

Makarand V. Risbud, Ph.D

pH Regulation and its Metabolic Consequences in Intervertebral Disc Health and Disease

Thomas Jefferson University
July 1, 2019, 11h00 - Amphi D. Escande(IRS-UN)

 

JFBTM Award for Giulia Frangi

Congratulations to Giulia Frangi who obtained the JFBTM Award for the best oral presentation "Young Researcher" for her talk entitled : "Altered bone marrow adiposity in pit2-deficient mice" (Boulogne/mer, June 5-7, 2019)

PhD Defense of Killian Flégeau

Killian defended his thesis on April 24, 2019, at 14.00 pm

Développement et caractérisation d'hydrogels d'acide hyaluronique auto-réticulants injectables en ingénierie tissulaire du squelette

Directeur de thèse: P. Weiss - Co-directeur : Hélène Gautier

ECTS, Hongrie 2019

Laurent Beck was invited to give a basic science update on phosphate sensing and to present Nina Bon's recently published work on this subject at the ECTS congress that took place in Budapest (10-15 may 2019)

New funding of SFR

SFR (Société Française de Rhumatologie) has decided to finance : REVAGO, headed by Angélique Galvani & Valérie Geoffroy. The aim of the REVAGO project is to explore an innovative communication network between bone cells based on extracellular vesicles (EVs), and elucidate its role during bone aging.

Dominique Pioletti, PhD

The role of dissipation in developing hydrogels with increased mechanical and mechanobiological properties

Laboratory of Biomechanical Orthopedics,EPFL
April 24th, 2019, 11h00 - Amphi Ricordeau (Dental Faculty)

 

New funding of Fondation de l'Avenir

Fondation de l'Avenir and his partner CDC Mutuelle have decided to fund our project entitled "Intra-articular injection of mesenchymal stem cells: evaluation in a humanized model of surgically induced osteoarthritis", headed by Prof. C. Le Visage. As a part of this new collaboration, they visited our lab on Feb. 22 and had discussion with the team involved in this project". Article...

I-site NExT Award for Vianney Delplace

Recently awarded a postdoctoral fellowship by the French Foundation for Medical Research (FRM), Vianney Delplace has obtained a 3-year financial support of 500 K€ from the i-site NExT (Nantes Excellence Trajectory) program, as a « junior talent ». Starting his own group within the RMeS Lab (INSERM 1229), Vianney will develop innovative hydrogel-based strategies for cartilage repair. Welcome on board, Vianney!

Bioregate Award for Leslie Frapin

Congratulations to Leslie Frapin who obtained the Bioregate Award for the best oral presentation "Young Researcher" for her talk entitled : "Controlled release of biological factors for progenitor cell-mediated endogenous repair of intervertebral discs".

Tilman Award for Benoit Métayer

Congratulations to Benoit Metayer who obtained the Osteoarthritis Foundation Tilman Award for his work entitled : "Development of an osteoarthritis model in humanized mice to study the therapeutic effects of encapsulated human mesenchymal stem cells".

La Microscopie Electronique pour les Sciences du Vivant

June 21, 2019 - Nantes (Cité des Congrès de Nantes)

Organized by J. Guicheux, E. Ishow, G. Loussouarn, P. Moreau, B. Novales, P. Paul-Gilloteaux, C. Vinatier .
Website

DEVSTEM 2019

The DEVSTEM meeting took place on June 4, 2019 at 10.00 am in the School of dental Surgery (Amphi Landais). Presentations of N. Vedrenne & Méryl Roudaut

EMBO Workshop

12-16 May 2019 - Le Pouliguen

Organized by Dr A. Camus, Dr C. Lamaze, Dr S. Le Lay, Pr A. Kenworthy, Pr M. Del Pozo & dedicated to the Caveolae and nanodomains: Translating structural principles and dynamics into function .
Website

 

PhD Defense of Amadou Toure

Amadou Toure defended his thesis on December 19, 2018, at 9.30 am

Contribution au développement de substituts osseux auto-réticulants en ingénierie tissulaire osseuse maxillo-faciale

Directeur de thèse: P. Weiss - Co-directeur : B. Giumelli. Congratulations Amadou !

NexT Initiative Research Grant

The STEP team is pleased to announce the funding of the SHELBY project by the NEXT initiative of the Nantes University (Internal Interdisciplinary Projects). SHELBY will be coordinated by Catherine Le Visage in collaboration with Claire Vinatier and Jerome Guicheux from RMeS laboratory, Denis Renard from the BIA laboratory (INRA UR 1268, Nantes) and Arnaud Tessier from the CEISAM laboratory (UMR CNRS 6230, Nantes). SHELBY will aim at developing a new generation of functionalized boronic acid hydrogels with self-healing properties and evaluating their ability to encapsulate mesenchymal stem cells and prevent osteoarthritis. The SHELBY project is funded for 1 year with possible extension up to 4 years and will be developed in the framework of Fabien Nativel’s PhD Thesis.

Marie-Michèle Germaini

Marie-Michèle is post-doc. She will work on 3D biomimetic 3D printing cement for personalized repair of alveolar cleft. She will work on printable formulation of calcium phosphate cement using hydrogels in collaboration with GPEA, LS2N and INRA. She is implicated in the bioregate 3D refentine program coordinated by Pierre Corre. The objective is building adapted 3D bone scaffold for children with cleft palate.

She joined the REGOS team on Oct. 1st 2018

Congratulations to Lara Figueiredo !

Lara Figueiredo defended her thesis on September 17, 2018, at 2.00 pm (Amphi Ricordeau, Dental Faculty)

3D biomimetic matrices to design in vitro stem cell niches

HDR of Zahi Badran

Zahi defended his HDR on February 9, 2018