RMeS in the spotlight

The RMeS laboratory is pleased to announce that Jérôme Guicheux (Director of the RMeS laboratory and head of the REJOINT team) is the winner of the Guillaumat-Piel 2022 Prize of the Foundation for Medical Research (FRM). This prize rewards research in the field of osteoarticular diseases and underlines the excellence of the work carried out by all the members of the team. This prize was awarded during the annual ceremony organized by the FRM on November 29, 2022 at the Collège de France under the auspices of the Minister of Higher Education and Research and the Minister of Health. Many thanks to the FRM.



Quand RMeS lève des fonds pour la Fondation Avenir de Recherche Médicale Appliquée lors d'un match du championnat de France de basket



 

Announcements


Bourse novartis DREAMER
Dr Christelle DARRIEUTORT-LAFFITE
Sujet de recherche : Etude de la cicatrisation d’un défect tendineux du supra-épineux chez la souris : analyse transcriptomique des populations cellulaires impliquées  

Description du projet :
Résumé : Bien que les tendinopathies représentent une problématique médicale fréquente, les options thérapeutiques restent peu nombreuses. Le tendon ayant une faible vascularisation et une faible cellularité, ses capacités naturelles de régénération/réparation sont faibles. Ce contexte, associé à nos connaissances limitées de la biologie des cellules du tendon et de la régulation de la ténogenèse, font du traitement des tendinopathies un réel challenge médical et scientifique. Des données récentes issues du Single-cell RNA-Sequencing démontrent la présence de populations de ténocytes hétérogènes au sein du tendon sain. Aucune donnée n’est disponible sur les changements au sein de ces populations cellulaires après une lésion tendineuse.
Objectifs : Etudier par Single-Cell RNA-Sequencing les populations cellulaires présentes au sein du tendon lors des différentes phases de la cicatrisation après une lésion partielle induite chirurgicalement au niveau du supra-épineux. Les échantillons seront recueillis à différents temps : en phase inflammatoire (J7), à la phase de prolifération (J21) et lors de la phase de remodelage (J42). Les échantillons seront également étudiés en histologie et immunohistochimie aux différents temps expérimentaux.


 

ANR
ANR NEMESIS

Low back pain (LBP) has been associated with intervertebral disc (IVD) degeneration. The recent identification of the microRNA (miR) role in IVD biology and degeneration allows considering miRs as new targets, but also as new potential therapeutic agents. The development of in vivo delivery systems, particularly miR-loaded nanocarriers, has thus been an area of active research. As a whole, the objectives of the NEMESIS project are (i) to set-up the formulation and characterization of miR-loaded nanocarriers, (ii) to implement potency assays and assess the interactions of miR-loaded nanocarriers with target cells in vitro and in an ex vivo whole IVD culture system and (iii) to establish the proof of concept of miR-loaded nanocarriers as a new therapeutic option in the management of DDD in an ovine preclinical model and in canine clinical trials. The NEMESIS project is based on an inter- and multi-disciplinary consortium composed of J. Clouet (scientific leader, RMeS lab), M. Fusellier (scientific co-leader, RMeS lab and ONIRIS) and Elise Lepeltier (scientific partner, MINT lab, Angers).
 

ATIP-Avenir SAMBA

Mandibular atrophy induced by the lack of a proper dentition is a major medical and socio-economic burden worldwide: the remaining bone volume is not sufficient to place dental implants to restore physiological functions. Although bone augmentation procedures exist, they are often heavy and complex, costly, and not deprived of risks (e.g., autologous bone graft). The ATIP-Avenir SAMBA program (INSERM/CNRS) will allow for the creation of a new group in RMeS Lab to tackle this issue, by developing among others 3D-printed patient specific biomimetic scaffolds for bone regeneration.

 

MiRbone By SFR

Age-related bone loss is a major medical and socio-economic problem worldwide. Many microRNAs are involved in bone homeostasis and may play a role in the development of osteoporosis. In the miRbone project funded by the SFR, Valérie Geoffroy and Frédéric Jehan (REGOS team) propose to dissect, using an "omic" approach, the mode of regulation of bone metabolism by one of these microRNAs, miR-199a2, whose significant effect in bone mass accrual has been demonstrated, with the aim of identifying new therapeutic targets to improve the management of bone loss in elderly patients.

 

ANR ANR-DYNAM-OA


Osteoarthritis (OA) has no cure to date. To identify new therapeutic targets and screen drugs, researchers need in vitro OA joint models that are biologically relevant and reproducible. Bioprinting-assisted OA modeling is a promising avenue of research, yet bioprinting tools are limited. With the DYNAM-OA project, Vianney Delplace (BIOMAX group) propose to develop a new ultra-modular bioprinting toolbox, including a universal bioink platform and a strategy to produce gradient constructs, and apply these tools for the design of the first generation of bioprinted OA joint models.

 

ANR ANR-COBIOSTEM


Traumatic brain injuries (TBI) are a critical public health and socio-economic problem throughout the world, with limited treatment options available. Cell transplantation offers a viable treatment strategy for patients with TBI, but transplanted neurons alone often rapidly die and fail to integrate brain tissue, leading to limited recovery. In the COBIOSTEM project, led by Afsaneh Gaillard (INSERM U1084 - LNEC), Vianney Delplace (BIOMAX group) will design a new generation of injectable hydrogels to improve the survival rate of transplanted cortical neurons, and enhance the long-term efficacy of cell transplantation to the brain.
 

International Research Project (IRP) Inserm (2022) GLYCODISC


The goal of the GLYCODISC projet is to consolidate a cooperating relationship between France (PI: Catherine LE VISAGE, Inserm) and Hong Kong (PI: Barbara CHAN, The University of Hong Kong (HKU)), in the field of regenerative medicine for intervertebral disc disease and low back pain.
The funding (75 000 euros, duration 5 years) aims to primarily contribute to mobility and organization of meetings. The ultimate outcome of the program is to lay the foundation for a large-scale international collaborative project with scientists from both countries.
 

ANR ANR SmartIEs (2022)


The REJOINT team of the INSERM U1229-RMeS laboratory is pleased to announce the recent funding of the SmartIEs proposal as an ANR collaborative research project.
SmartIEs will be coordinated by Sylvia COLLIEC-JOUAULT (IFREMER) and will be carried out in collaboration with Stéphane CUENOT (Institut des Matériaux) and Catherine Le Visage (INSERM U1229, RMeS). The SmartIEs project will explore a cell-free strategy through conception of a smart hydrogel scaffold highly efficient to recruit regenerative progenitor cells and to stimulate their differentiation into appropriate cell lineages able to regenerate both cartilage and subchondral bone.

Publications


 

PPARβ/δ-Interfering Peptide Enhanced Mesenchymal Stromal Cell Immunoregulatory Properties

Gautier Tejedor,Prisca Boisguerin, Éric Vivès, Christian Jorgensen, Jérôme Guicheux, Claire Vinatier, Claire Gondeau, and Farida Djouad

Stem Cells International

Abstract and more




Transition from continuous to microglobular shaped peptide assemblies through a Liesegang-like enzyme-assisted mechanism.

Runser J-Y, Fneich F, Senger B, Weiss P, Jierry L,  Schaaf P

Journal of Colloid and Interface Science, 2022 Nov 22


Abstract and more



IL-34 deficiency impairs FOXP3+ Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.

Freuchet A, Salama A, Bézie S, Tesson L, Rémy S, Humeau R, Règue H, Sérazin C, Flippe L, Peterson P, Vimond N, Usal C, Ménoret S, Heslan JM, Duteille F, Blanchard F, Giral M, Colonna M, Anegon I, Guillonneau C.
Clin Transl Med. 2022 Aug;12(8):e988. doi: 10.1002/ctm2.988.
Abstract and more




oral

Bone characteristics in condylar hyperplasia of the temporomandibular joint: a microcomputed tomography, histology, and Raman microspectrometry study.

Kün-Darbois JD, Bertin H, Mouallem G, Corre P, Delabarde T, Chappard D.

Int J Oral Maxillofac Surg. 2022 Sep 27

Abstract and more

 

joint bone spine Update on contribution of hip labral tears to hip pain: a narrative review.

Berthelot JM, Brulefert K, Arnolfo P, Le Goff B, Darrieutort-Laffite C.

Joint Bone Spine. 2022 Sep 20


Abstract and more




int j mol Modulators of Wnt Signaling Pathway Implied in Dentin Pulp Complex Engineering: A Literature Review.
Florimond

M, Minic S, Sharpe P, Chaussain C, Renard E, Boukpessi T.

Int J Mol Sci. 2022 Sep 13

Abstract and more



 

New members








Lea Terriac

octave bandiaky
Gaegard Nicolas

dulom arnaud
danet lucie
 

PhD defense & HDR


 



Soutenance de thèse Mélina Georget le mercredi 1 février 2023 à 14h

" Mise au point d’un modèle de sénescence chondrocytaire et rôle de la O-GlcNAcylation dans l’arthrose"

- Mots clés: arthrose, sénescence, O-GlcNAcylation.