Slc20a2, encoding the phosphate transporter PiT2, is an important genetic determinant of bone quality and strength

Beck-Cormier S, Lelliott CJ, Logan JG, Lafont DT, Merametdjian L, Leitch VD, Butterfield NC, Protheroe HJ, Croucher PI, Baldock PA, Gaultier-Lintia A, Maugars Y, Nicolas G, Banse C, Normant S, Magne N, Gérardin E, Bon N, Sourice S, Guicheux J, Beck L, Williams GR, Bassett JHD

J Bone Miner Res. 2019 Feb 5 - Download full text

Journal of Stomatology
Comparing "intra operative" tissue engineering strategies for the repair of craniofacial bone defects

Hivernaud V, Grimaud F, Guicheux J, Portron S, Pace R, Pilet P, Sourice S, Wuillem S, Bertin H, Roche R, Espitalier F, Weiss P, Corre P

J Stomatol Oral Maxillofac Surg. 2019 Jan 11 - Download full text

current molecular biology
Animal models of phosphorus homeostasis

Beck L and Sitara D

Current Molecular Biology Reports pp 1–14

current molecular biology
Interplay Between FGF23, Phosphate, and Molecules Involved in Phosphate Sensing

Nina Bon, Sarah Beck-Cormier, Laurent Beck

Current Molecular Biology Reports pp 1–7


nextI-site NExT Award for Vianney Delplace

Recently awarded a postdoctoral fellowship by the French Foundation for Medical Research (FRM), Vianney Delplace has obtained a 3-year financial support of 500 K€ from the i-site NExT (Nantes Excellence Trajectory) program, as a « junior talent ». Starting his own group within the RMeS Lab (INSERM 1229), Vianney will develop innovative hydrogel-based strategies for cartilage repair. Welcome on board, Vianney!

Leslie AwardBioregate Award for Leslie Frapin

Congratulations to Leslie Frapin who obtained the Bioregate Award for the best oral presentation "Young Researcher" for her talk entitled : "Controlled release of biological factors for progenitor cell-mediated endogenous repair of intervertebral discs".

Prix Fondation ArthroseTilman Award for Benoit Métayer

Congratulations to Benoit Metayer who obtained the Osteoarthritis Foundation Tilman Award for his work entitled : "Development of an osteoarthritis model in humanized mice to study the therapeutic effects of encapsulated human mesenchymal stem cells".

H2020An additional Horizon 2020 European research grant for INSERM UMR 1229-RMeS towards treating chronic back pain

In 2016, the European commission invested 5.5 millions Euros in the RESPINE project to clinically address whether bone marrow-derived mesenchymal stromal cells may help solve low back pain that affects hundreds of millions of patients worldwide. The double blind phase 2b RESPINE clinical trial (P.I. Christian Jorgensen, Montpellier University Hospital; EudraCT 2017-002092-25) is now recruiting more than 100 patients in France and European countries. Jerome Guicheux (Nantes scientific coordinator, STEP Team, INSERM UMR 1229-RMeS) is a task leader in this project in charge of developing cutting-edge potency assays for the preclinical evaluation of the regenerative potential of stem cells (Cécile Boyer). Fifteen patients will be recruited at the Nantes University Hospital in the department of neurotraumatology and neurosurgery (Eric Bord). After the successful funding of RESPINE, the STEP team of the INSERM UMRS 1229-RMeS is now pleased to announce the recent selection of the H2020 iPSpine project by the European commission. iPSpine will receive an overall grant of 15 M€. This large European consortium will gather 20 international partners and will be coordinated by Marianna Tryfonidou (Utrecht University, The Netherlands). This project will officially be launched in February 2019 and it will deal with the development of advanced therapy medicinal products based on the use of biomaterials and induced-pluripotent stem cells (iPSC) towards solving intervertebral disc (IVD) degeneration. Jerome Guicheux is the scientific coordinator of iPSpine workpackage (WP) 1 “iPSC development, differentiation and technologies” that gathers 7 international partners and focus on discovering innovative culture protocols for the generation of IVD cells derived from human iPSC (Anne Camus). In collaboration with the ONIRIS-national veterinary school of Nantes, the STEP team will also participate in WPs 3 and 6 respectively dedicated to (i) in vitro 3D cell culture (Catherine Le Visage, RMeS) and (ii) the first canine clinical trial related to the efficacy of the intradiscal injection of iPSC-derived regenerative cells in the treatment of low back pain (Marion Fusellier & Johann Clouet). RMeS will receive a global support of about 1.3 million Euros and will recruit 1 post-doc, 2 research assistants and 1 clinical assistant.

Workshops & symposia

Termis Meeting, 27th-31st May 2019, Rhodes, Greece

Several members of our unit organize symposia during this conference :

  • Vianney Delplace & Pierre Weiss : "From innovative hydrogel chemistry to musculoskeletal regeneration approaches"
  • Catherine Le Visage & Valérie Geoffroy: "MSC-derived Extracellular Vesicles: from production, engineering and administration challenges to bone tissue regenerative therapies"
  • Jérome Guicheux & Marianna Trifonnidou: Advanced therapies of the future for spinal regeneration: The H2020 European iPSpine project
  • Claire Vinatier & Anne Desrieux : "New frontiers in osteoarthritis treatment: prospects for stem cells, extracellular vesicles and biomaterials-assisted cell therapies"


Dominique PiolettiDominique Pioletti, PhD

The role of dissipation in developing hydrogels with increased mechanical and mechanobiological properties

Laboratory of Biomechanical Orthopedics,EPFL
April 24th, 2019, 11h00 - Amphi Ricordeau (Dental Faculty)


Guillaume MabilleauGuillaume Mabilleau, PhD

Gut hormones and bone quality

March 19th, 2019, 11h00 - Amphi Ricordeau (Dental Faculty)


New members

Pierre-Guillaume PiriouPierre-Guillaume Piriou

Pierre-Guillaume is a M2 student.
He will work on the evaluation of the biomechanical characteristics of coronary stents and their performance in simple model and bifurcation model.

He joined our unit on Jan. 28th 2019
His supervisors are Thierry Rouillon & Fabienne Jordana

Cassandra LepetitCassandra Lepetit

Cassandra is a M2 student.
She will work on the resolution of inflammation in clinical situations

She joined our unit on Jan. 7th 2019
Her supervisor is Alexis Gaudin

Edouard SamarutEdouard Samarut

Edouard is a M2 student.
He will work on REMEDIV & BIO2/STIMUDISC projects

He joined our unit on Jan. 7th 2019
His supervisor is Johann Clouet

Nathan LagneauNathan Lagneau

Nathan is a M2 student.
He will work on Shelby project

He joined our unit on Jan. 7th 2019
His supervisor is Vianney Delplace

Mélanie LefebvreMélanie Lefebvre

Mélanie is a M2 student.
She will work on Shelby project

She joined our unit on Jan. 7th 2019
Her supervisor is Vianney Delplace

PhD defense & HDR

Maude GluaisPhD Defense of Maude Gluais

Maude Gluais defended her thesis on December 18, 2018, at 14.00 pm

Mise au point et évaluation de biomatériaux électrospinés pour la régénération de l’Annulus fibrosus

Directeur de thèse: C. Le Visage- Co-directeurs : J. Guicheux/J. Clouet. Congratulations Maude !

Amadou TourePhD Defense of Amadou Toure

Amadou Toure defended his thesis on December 19, 2018, at 9.30 am

Contribution au développement de substituts osseux auto-réticulants en ingénierie tissulaire osseuse maxillo-faciale

Directeur de thèse: P. Weiss - Co-directeur : B. Giumelli. Congratulations Amadou !

Alexandra CloitrePhD Defense of Alexandra Cloitre

Alexandra Cloitre defended her thesis on December 19, 2018, at 1.30 pm

La destruction osseuse parodontale : physiopathogénie et rôle des nouvelles interleukines

Directeur de thèse: P. Lesclous - Co-directeur : V. Geoffroy. Congratulations Alexandra !

And among other things...

General Assembly 2018
RMeS General Assemby (Campus Gavy - St Nazaire) -
May 14th, 2018

Photo Fête de Noël
Christmas Party RMeS ! December 18th, 2017

Olympiades RMES

The 2nd Edition of the RMeS "Olympiades" has taken place on Sept. 18th, 2017. 4 teams have met in good spirits. Thanks to all the participants!