Role of good oral hygiene on clinical evolution of rheumatoid arthritis: a randomized study nested in the ESPOIR cohort.

Mariette X, Perrodeau E, Verner C, Struillou X, Picard N, Schaeverbeke T, Constantin A, Ravaud P, Bouchard P

Rheumatology (Oxford). 2019 Sep 3 - Download full text

Periodontal regenerative medicine using mesenchymal stem cells and biomaterials: A systematic review of pre-clinical studies.

Portron S, Soueidan A, Marsden AC, Rakic M, Verner C, Weiss P, Badran Z, Struillou X

Dent Mater J. 2019 Sep 11 - Download full text

advanced drug delivery reviews
Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors

Frapin L, Clouet J, Delplace V, Fusellier M, Guicheux J, Le Visage C

Adv Drug Deliv Rev. 2019 Aug 21 - Download full text

Caveolae: The FAQs

Parton RG, Del Pozo MA, Vassilopoulos S, Nabi IR, Le Lay S, Lundmark R, Kenworthy AK, Camus A, Blouin CM, Sessa WC, Lamaze C

Traffic. 2019 Aug 26. - Download full text



FNSNF ET ANRNew funding of FNSRS & ANR

The STEP team is pleased to announce that the INDEED project (International Collaborative Research Project - PRCI) led by Matteo D'Este (AO Research Institute, Switzerland) and Christophe Helary (UMR 7574, Sorbonne University- CNRS, France) in partnership with RMeS (INSERM U1229-ONIRIS-Nantes University, France) and the Biomechanical Institute (ETH, Switzerland) has been selected for funding by the Swiss national fund for scientific research (FNSRS) and the french research agency (ANR). The main objective of INDEED is to develop a 3D model of intervertebral disc (IVD) by bio-impression. Composite inks based on hyaluronic acid and collagen will be synthesized (UMR 7574) and their interactions with IVD cells will be characterized (UMR 1229). The mechanical (ETH) and biological (ARI) properties of this bio-printed IVD will be compared to those of animal and human discs. This disc model will also be used to decipher the molecular mechanisms of disc degeneration at the origin of low back pain but also for the screening of new therapeutic agents, thus contributing to reduce the use of animal experiments.

ANRNew funding of ANR 2019

The STEP team of the INSERM U1229-RMeS laboratory is pleased to announce the recent funding of the EXCELLDISC proposal as an ANR collaborative research project. EXCELLDISC will be coordinated by Catherine Le Visage (INSERM U1229, RMeS) and will be carried out in collaboration with Florence Gazeau (MSC CNRS 7087) and Grégory Lavieu (U932, Institut Curie). EXCELLDISC will investigate whether MSC-derived extracellular vesicles (EVs) could contribute to slow down, stop or reverse intervertebral disc degeneration. .

ANRNew funding of ANR JCJC 2019

The REGOS team of the INSERM U1229-RMeS laboratory is pleased to announce the success of the BILIPOX project in ANR JCJC 2019. The laboratory will receive a grant of 305k€ for 3 years to hire dedicated staff (Engineer and technician). The BILIPOX project will be coordinated by Alexis Gaudin and will be carried out in collaboration with Christophe Blanquart (CRCINA, INSERM UMR 1232), Philippe Legrand (UMR 5253 CNRS- UM-ENSCM), Jeff Johnson (Cayman Chemical Company) and Stéphane Simon (University Paris Diderot (Paris VII). The specific goal of this project is to evaluate the potential benefits of a new biphasic microgel as lipoxin A4 (LXA4) delivery system for tissue engineering (pulp and periodontal tissue). The results of BILIPOX may provide a better understanding of microgels/macrophage interaction. This would be an important milestone for hydrogels modular strategy that open a new way to design and to multi-functionalize drug delivery systems.

nextNew funding of NExT

The STEP team of the INSERM U1229-RMeS laboratory is pleased to announce the success of the SHELBY project in phase 2 of the NExT IIP (Internal interdisciplinary projects) call of proposals. The laboratory will receive a grant of 140 k€ for 3 years to hire dedicated staff (PhD student or engineer). The SHELBY project will be coordinated by Catherine Le Visage and will be carried out in collaboration with Denis Renard (INRA BIA) and Arnaud Teissier (CEISAM, CNRS). The objectives of this project are to develop innovative hydrogels for stem cell encapsulation by lithography, with particular application to cell therapy of disc or peripheral osteoarthritis.

Workshops & symposia

Termis Meeting, 27th-31st May 2019, Rhodes, Greece

Several members of our unit organize symposia during this conference :

  • Vianney Delplace & Pierre Weiss : "From innovative hydrogel chemistry to musculoskeletal regeneration approaches"
  • Catherine Le Visage & Valérie Geoffroy: "MSC-derived Extracellular Vesicles: from production, engineering and administration challenges to bone tissue regenerative therapies"
  • Jérome Guicheux & Marianna Trifonnidou: Advanced therapies of the future for spinal regeneration: The H2020 European iPSpine project
  • Claire Vinatier & Anne Desrieux : "New frontiers in osteoarthritis treatment: prospects for stem cells, extracellular vesicles and biomaterials-assisted cell therapies"


Grégory LavieuGrégory Lavieu, Ph.D

Cellular Aspects of Extracellular Vesicle Delivery

Institut Curie
Oct. 16, 2019, 11h00 - Amphi D. Escande(IRS-UN)


chuCHU de Nantes/SNITEM

Journée d'information & d'échange sur les dispositifs médicaux à l'hôpital : Du laboratoire au lit du patient

November 13th, 2019, from 9h00 - Auditorium du Musée d’Arts de Nantes – 10 rue Georges-Clemenceau, 44000 Nantes


RMeS in the spotlight

icrsICRS World congress, Vancouver 2019

Jérôme Guicheux has been invited to give a Key note on "Exploring Stem Cells & Biomaterials for Regenerative Medicine of Intervertebral Disc: From Clinical Data to Innovative Concepts" at the ICRS World congress that is organized in Vancouver (5-9 October 2019). ICRS is the International Cartilage Regeneration & Joint Preservation society

talk ambassy1st France-USA Stem cell Symposium, Los Angeles 2019

Jérôme Guicheux has been invited to give a talk on "Stem cells and biomaterials for spinal joint regenerative medicine : from biologically inspired concepts to clinical transfer" at the 1st France-USA Stem cell symposium that took place in Los Angeles (June 25th, 2019)

intervention rouenSNMS, Rouen 2019

Jérôme Guicheux has been invited to give a talk on stem cells and regenerative medicine: "Cellules souches et médecine régénératrice des articulations : la route est-elle encore longue ?"at the SNMS congress that took place in Rouen (June 8th, 2019)

New members

Mélina GeorgetMélina Georget

Mélina is a PhD student. She will study the role of senescence in osteoarthritis and explore new anti-aging strategies to treat osteoarthritis.

She joined our unit on Sept. 9th 2019
Her supervisors are Dr C Vinatier and Pr G Grimandi

Caroline ChariauCaroline Chariau

Caroline (ass. ing. ) will work on Notochordal differentiation and stem cell-based therapy for intervertebral disc degeneration (H2020 iPSpine project; agreement No 825925)

She joined our unit on March 11th 2019
Her supervisor is Anne Camus

Nicolas VedrenneNicolas Védrenne

Nicolas is post-doctoral researcher
He will work on Notochordal differentiation and stem cell-based therapy for intervertebral disc degeneration (H2020 iPSpine project)

He joined our unit on March 11th 2019
His supervisor is Anne Camus

PhD defense & HDR

Pierre TournierPhD Defense of Pierre Tournier

Pierre will defend his thesis on December 18, 2019, at 14.00 pm (Amphi Ricordeau)

Caractérisation biologique d'une pâte osseuse allogénique pour la médecine régénératrice du squelette

Directeur de thèse: P. Weiss - Co-directeur : J. Guicheux - Co-encadrant : A. Gaudin

Leslie FrapinPhD Defense of Leslie Frapin

Leslie will defend her thesis on December 11, 2019, at 14.00 pm (Amphi D. Escande)

Ingénierie tissulaire du disque intervertébral: Développement d'un système à libération séquentielle de facteurs biologiques pour la réparation endogène du disque intervertébral humain

Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux - Co-encadrant : J. Clouet

Photo thèse ArnaudPhD Defense of Arnaud Paré

Arnaud defended his thesis on July 11, 2019, at 14.00 pm (Amphi Ricordeau)

Rôle de l'apport du dioxygène dans la régénération osseuse en zone ischémique: application aux défauts osseux mandibulaires interrupteurs

Directeur de thèse: P. Corre - Co-directeur : Olivier Gauthier

And among other things...

General Assembly 2018

RMeS General Assemby (Campus Gavy - St Nazaire) -
May 14th, 2018

Photo Fête de Noël
Christmas Party RMeS ! December 18th, 2017

Olympiades RMES

The 2nd Edition of the RMeS "Olympiades" has taken place on Sept. 18th, 2017. 4 teams have met in good spirits. Thanks to all the participants!