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Inserm osteoarthritis research network

Peripheral and spine osteoarthritis: from pathophysiology to transformative therapeutics

1st NetwOArk Autumn School

November 23rd, 2023, Buffon Amphitheatre - 15 rue Hélène Brion, Paris 13, France

Invitation and Call for oral presentations

The Inserm and ITMO PMN are happy to announce the First OsteoArthritis research Network (NetwOArk) Autumn School to be held on November 23rd, 2023 in the Buffon Amphitheatre (15 rue Hélène Brion - Paris 13). The aim of this meeting is to facilitate interactions between senior and junior researchers working in the field of osteoarthritis.

The Inserm osteoarthritis research network (NetwOArk) aims to bring together all the scientific actors involved in research on osteoarthritis, in order to federate and promote the emergence of high-level scientific work in this field. NetwOArk is supported by Inserm and the life science Institute Pathophysiology Metabolism Nutrition (IT PMN).

Coordinators: Jérôme Guicheux (INSERM U1229, Nantes Université), Francis Berenbaum (INSERM U938, Sorbonne Université).

More informations	Abstract Submission
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RMeS in the spotlight

La Science, CQFD

Quelles sont les pistes thérapeutiques à l’étude pour traiter l'arthrose ?

Claire Vinatier Enseignante-chercheuse à l’Université de Nantes, au laboratoire Hermes, de médecine régénératrice et squelette.

Francis Berenbaum Chef de service de rhumatologie au CHU Saint-Antoine de l’APHP.

Ecouter l'émission radio : https://www.radiofrance.fr/franceculture/podcasts/la-science-cqfd/mignonne-allons-voir-si-l-arthrose-8569072

Arthrose : des cellules souches encapsulées pour protéger l’articulation

Communication Grand Public

Lien vers l'article

La team @RMeS_UMR1229 a couru pour la bonne cause dimanche 19 mars. Un défi sportif solidaire contre le cancer du sein via l'association Odysséa (https://odyssea.info/qui-sommes-nous-odyssea/)

Magazine Fondation de l'avenir : Lombalgie : régénérer les disques intervertébraux

Announcements

L’exploration du rôle de la senescence cellulaire dans la maladie discale soutenue par la SFR

Dans le cadre de sa subvention aux projets individuels de recherche, la Société Française de Rhumatologie (SFR) a attribué une bourse [de 20000€] au projet « MoSCITO » porté par Romain GUIHO (La MOdulation de la Sénescence Cellulaire comme Innovation Thérapeutique dans la discOpathie dégénérative). En plus de faire progresser considérablement la caractérisation des cellules sénescentes dans le disque intervertébral, le projet MoSCITO a l'ambition de valider une nouvelle approche thérapeutique, ouvrant la voie à des progrès concrets et considérables dans la gestion clinique de la maladie discale.

A new collaborative project funded by the SFR: Characterization and new therapeutic options for pigmented villonodular synovitis (PVNS). It will be coordinated by Benoit Le Goff and Frédéric Blanchard in collaboration with Fabienne Coury (INSERM UMR1033, Lyon) and Jérôme Avouac (INSERM U1016 Paris). This project aims to
- set up a multicentric biocollection of patients with PVNS;
- explore the mechanisms leading to the development of synovitis (inflammation, genetic mutations, vascular compartment) using high-throughput technologies
- evaluate in vitro the biological activity of several drugs, in particular those targeting the CSF1 pathway, on tissues /cells from PVNS patients.

Bourse novartis DREAMER
Dr Christelle DARRIEUTORT-LAFFITE
Sujet de recherche : Etude de la cicatrisation d’un défect tendineux du supra-épineux chez la souris : analyse transcriptomique des populations cellulaires impliquées

Description du projet :
Résumé : Bien que les tendinopathies représentent une problématique médicale fréquente, les options thérapeutiques restent peu nombreuses. Le tendon ayant une faible vascularisation et une faible cellularité, ses capacités naturelles de régénération/réparation sont faibles. Ce contexte, associé à nos connaissances limitées de la biologie des cellules du tendon et de la régulation de la ténogenèse, font du traitement des tendinopathies un réel challenge médical et scientifique. Des données récentes issues du Single-cell RNA-Sequencing démontrent la présence de populations de ténocytes hétérogènes au sein du tendon sain. Aucune donnée n’est disponible sur les changements au sein de ces populations cellulaires après une lésion tendineuse.
Objectifs : Etudier par Single-Cell RNA-Sequencing les populations cellulaires présentes au sein du tendon lors des différentes phases de la cicatrisation après une lésion partielle induite chirurgicalement au niveau du supra-épineux. Les échantillons seront recueillis à différents temps : en phase inflammatoire (J7), à la phase de prolifération (J21) et lors de la phase de remodelage (J42). Les échantillons seront également étudiés en histologie et immunohistochimie aux différents temps expérimentaux.

ANR NEMESIS

Low back pain (LBP) has been associated with intervertebral disc (IVD) degeneration. The recent identification of the microRNA (miR) role in IVD biology and degeneration allows considering miRs as new targets, but also as new potential therapeutic agents. The development of in vivo delivery systems, particularly miR-loaded nanocarriers, has thus been an area of active research. As a whole, the objectives of the NEMESIS project are (i) to set-up the formulation and characterization of miR-loaded nanocarriers, (ii) to implement potency assays and assess the interactions of miR-loaded nanocarriers with target cells in vitro and in an ex vivo whole IVD culture system and (iii) to establish the proof of concept of miR-loaded nanocarriers as a new therapeutic option in the management of DDD in an ovine preclinical model and in canine clinical trials. The NEMESIS project is based on an inter- and multi-disciplinary consortium composed of J. Clouet (scientific leader, RMeS lab), M. Fusellier (scientific co-leader, RMeS lab and ONIRIS) and Elise Lepeltier (scientific partner, MINT lab, Angers).

ATIP-Avenir SAMBA

Mandibular atrophy induced by the lack of a proper dentition is a major medical and socio-economic burden worldwide: the remaining bone volume is not sufficient to place dental implants to restore physiological functions. Although bone augmentation procedures exist, they are often heavy and complex, costly, and not deprived of risks (e.g., autologous bone graft). The ATIP-Avenir SAMBA program (INSERM/CNRS) will allow for the creation of a new group in RMeS Lab to tackle this issue, by developing among others 3D-printed patient specific biomimetic scaffolds for bone regeneration.

MiRbone By SFR

Age-related bone loss is a major medical and socio-economic problem worldwide. Many microRNAs are involved in bone homeostasis and may play a role in the development of osteoporosis. In the miRbone project funded by the SFR, Valérie Geoffroy and Frédéric Jehan (REGOS team) propose to dissect, using an "omic" approach, the mode of regulation of bone metabolism by one of these microRNAs, miR-199a2, whose significant effect in bone mass accrual has been demonstrated, with the aim of identifying new therapeutic targets to improve the management of bone loss in elderly patients.

ANR-DYNAM-OA

Osteoarthritis (OA) has no cure to date. To identify new therapeutic targets and screen drugs, researchers need in vitro OA joint models that are biologically relevant and reproducible. Bioprinting-assisted OA modeling is a promising avenue of research, yet bioprinting tools are limited. With the DYNAM-OA project, Vianney Delplace (BIOMAX group) propose to develop a new ultra-modular bioprinting toolbox, including a universal bioink platform and a strategy to produce gradient constructs, and apply these tools for the design of the first generation of bioprinted OA joint models.

ANR-COBIOSTEM

Traumatic brain injuries (TBI) are a critical public health and socio-economic problem throughout the world, with limited treatment options available. Cell transplantation offers a viable treatment strategy for patients with TBI, but transplanted neurons alone often rapidly die and fail to integrate brain tissue, leading to limited recovery. In the COBIOSTEM project, led by Afsaneh Gaillard (INSERM U1084 - LNEC), Vianney Delplace (BIOMAX group) will design a new generation of injectable hydrogels to improve the survival rate of transplanted cortical neurons, and enhance the long-term efficacy of cell transplantation to the brain.

International Research Project (IRP) Inserm (2022) GLYCODISC

The goal of the GLYCODISC projet is to consolidate a cooperating relationship between France (PI: Catherine LE VISAGE, Inserm) and Hong Kong (PI: Barbara CHAN, The University of Hong Kong (HKU)), in the field of regenerative medicine for intervertebral disc disease and low back pain.
The funding (75 000 euros, duration 5 years) aims to primarily contribute to mobility and organization of meetings. The ultimate outcome of the program is to lay the foundation for a large-scale international collaborative project with scientists from both countries.

ANR SmartIEs (2022)

The REJOINT team of the INSERM U1229-RMeS laboratory is pleased to announce the recent funding of the SmartIEs proposal as an ANR collaborative research project.
SmartIEs will be coordinated by Sylvia COLLIEC-JOUAULT (IFREMER) and will be carried out in collaboration with Stéphane CUENOT (Institut des Matériaux) and Catherine Le Visage (INSERM U1229, RMeS). The SmartIEs project will explore a cell-free strategy through conception of a smart hydrogel scaffold highly efficient to recruit regenerative progenitor cells and to stimulate their differentiation into appropriate cell lineages able to regenerate both cartilage and subchondral bone.

Publications

PPARβ/δ-Interfering Peptide Enhanced Mesenchymal Stromal Cell Immunoregulatory Properties

Gautier Tejedor,Prisca Boisguerin, Éric Vivès,Christian Jorgensen, Jérôme Guicheux, Claire Vinatier, Claire Gondeau, and Farida Djouad

Stem Cells International

Abstract and more

Transition from continuous to microglobular shaped peptide assemblies through a Liesegang-like enzyme-assisted mechanism.

Runser J-Y, Fneich F, Senger B, Weiss P, Jierry L, Schaaf P

Journal of Colloid and Interface Science, 2022 Nov 22

Abstract and more

IL-34 deficiency impairs FOXP3+ Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.

Freuchet A, Salama A, Bézie S, Tesson L, Rémy S, Humeau R, Règue H, Sérazin C, Flippe L, Peterson P, Vimond N, Usal C, Ménoret S, Heslan JM, Duteille F, Blanchard F, Giral M, Colonna M, Anegon I, Guillonneau C.
Clin Transl Med. 2022 Aug;12(8):e988. doi: 10.1002/ctm2.988.
Abstract and more

oral

Bone characteristics in condylar hyperplasia of the temporomandibular joint: a microcomputed tomography, histology, and Raman microspectrometry study.

Kün-Darbois JD, Bertin H, Mouallem G, Corre P, Delabarde T, Chappard D.

Int J Oral Maxillofac Surg. 2022 Sep 27

Abstract and more

Update on contribution of hip labral tears to hip pain: a narrative review.

Berthelot JM, Brulefert K, Arnolfo P, Le Goff B, Darrieutort-Laffite C.

Joint Bone Spine. 2022 Sep 20

Abstract and more

Modulators of Wnt Signaling Pathway Implied in Dentin Pulp Complex Engineering: A Literature Review.
Florimond
M, Minic S, Sharpe P, Chaussain C, Renard E, Boukpessi T.

Int J Mol Sci. 2022 Sep 13

Abstract and more