Vet Surg
Preliminary evaluation of an osteochondral autograft, a prosthetic implant, and a biphasic absorbable implant for osteochondral reconstruction in a sheep model

Olive M, Boyer C, Lesoeur J, Thorin C, Weiss P, Fusellier M, Gauthier O

Vet Surg. 2020 Jan 9 - Download full text

Degenerative lumbar disc disease: in vivo data support the rationale for the selection of appropriate animal models

Fusellier M, Clouet J, Gauthier O, Tryfonidou M, Le Visage C, Guicheux J.

Eur Cell Mater. 2020 Jan 6;39:18-47 - Download full text

Head Neck
Postimplantation radiation therapy in head and neck cancer patients: Literature review

Koudougou C, Bertin H, Lecaplain B, Badran Z, Longis J, Corre P, Hoornaert A

Head Neck. 2020 Jan 3 - Download full text

Laryngoscope Investig Otolaryngol.
Reconstruction of segmental mandibular defects: Current procedures and perspectives

Paré A, Bossard A, Laure B, Weiss P, Gauthier O, Corre P

Laryngoscope Investig Otolaryngol. 2019 Nov 22;4(6):587-596 - Download full text

Chondroprotective Properties of Human-Enriched Serum Following Polyphenol Extract Absorption: Results from an Exploratory Clinical Trial

Wauquier F, Mevel E, Krisa S, Richard T, Valls J, Hornedo-Ortega R, Granel H, Boutin-Wittrant L, Urban N, Berger J, Descamps S, Guicheux J, Vinatier CS, Beck L, Meunier N, Blot A, Wittrant Y

Nutrients. 2019 Dec 16;11(12) - Download full text


INSERMLaunching of the INSERM French network : NetwOArk

RMES is happy to announce the launching of the INSERM French network dedicated to peripheral and spine osteoarthritis : NetwOArk. Jerome Guicheux will serve NetwOArk as national coordinator with Francis Berenbaum as a co-coordinator. NetwOArk aims bringing together all the scientific actors involved in osteoarthritis research in order to federate and promote the emergence of high-level scientific works in this field. NetwOArk is created for 4 years and is supported by INSERM, Aviesan and ITMO PMN. NetwOArk is organized around 4 work packages coordinated by Claire Vinatier and Esther Potier (WP 1 pathophysiology), Khorng Ea and Yves-Marie Pers (WP2 disease bio markers), Christelle N’Guyen and Jeremy Sellam (WP3 prevention and treatment) and David Moulin and Emeline Perrier-Groult (WP4 innovation). A first scientific event will be organized in 2020 to gather the French actors involved in Osteoarthritis research. We hope to meet you all to share recent advances in basic, translational and clinical research dedicated to this incurable and disabling disease.

bioregateNew funding of BIOREGATE

The STEP team (UMR 1229 INSERM-Nantes University-ONIRIS) is pleased to announce that the project DISCODOG was awarded of BIOREGATE (Région Pays de la Loire) grant (veterinary clinic grant). The project is led by Johann CLOUET and Marion FUSELLIER. This project will be performed in collaboration with the MINT laboratory (INSERM 1066 CNRS 6021) in Angers (Elise LEPELTIER).The two objectives of DISCODOG are to develop a new therapeutic tool to treat discogenic lumbalgia, consisting in miRNA encapsulated in lipid nanocapsules and to validate a new method to detect early signs of disc degeneration in canine patients. After intradiscal injection in clinic dogs, security and efficacy of the treatment will be followed by the mean of orthopedic and neurologic examination as well as by MRI, during 6 months. 120 k€ will be dedicated to the DISCODOG project during 2 years. The project will begin during the first semester of 2020..

FNSNF ET ANRNew funding of FNSRS & ANR

The STEP team is pleased to announce that the INDEED project (International Collaborative Research Project - PRCI) led by Matteo D'Este (AO Research Institute, Switzerland) and Christophe Helary (UMR 7574, Sorbonne University- CNRS, France) in partnership with RMeS (INSERM U1229-ONIRIS-Nantes University, France) and the Biomechanical Institute (ETH, Switzerland) has been selected for funding by the Swiss national fund for scientific research (FNSRS) and the french research agency (ANR). The main objective of INDEED is to develop a 3D model of intervertebral disc (IVD) by bio-impression. Composite inks based on hyaluronic acid and collagen will be synthesized (UMR 7574) and their interactions with IVD cells will be characterized (UMR 1229). The mechanical (ETH) and biological (ARI) properties of this bio-printed IVD will be compared to those of animal and human discs. This disc model will also be used to decipher the molecular mechanisms of disc degeneration at the origin of low back pain but also for the screening of new therapeutic agents, thus contributing to reduce the use of animal experiments.

ANRNew funding of ANR 2019

The STEP team of the INSERM U1229-RMeS laboratory is pleased to announce the recent funding of the EXCELLDISC proposal as an ANR collaborative research project. EXCELLDISC will be coordinated by Catherine Le Visage (INSERM U1229, RMeS) and will be carried out in collaboration with Florence Gazeau (MSC CNRS 7087) and Grégory Lavieu (U932, Institut Curie). EXCELLDISC will investigate whether MSC-derived extracellular vesicles (EVs) could contribute to slow down, stop or reverse intervertebral disc degeneration. .


Arnaud ScherberichDr. Arnaud Scherberich

Adipose-derived cells for bone regeneration: Generation of bone germs, developmental engineering and use of nanoparticles

University of Bâle
Jan 8, 2020, 11h00 - Amphi Landais (Dental Faculty)

Fan YangProf. Fan Yang

From Zip lining to Lego building: Novel Hydrogels for Stem Cell-based Tissue Regeneration and Disease Modeling

University of Stanford
Jan 17, 2020, 14h30 - Amphi Landais (Dental Faculty)

Julien NicolasDr. Julien Nicolas

Advanced macromolecular engineering: from biodegradable vinyl materials to anticancer polymer prodrugs

Institut Galien Paris-Sud, CNRS UMR 8612
March 10, 2020, 11h00 - Amphi Ricordeau (Dental Faculty)

RMeS in the spotlight

LYOSJ. Guicheux's talk - Rencontres du Lyos (Lyon, 15/11/2019)

Presentation of Jérôme Guicheux at : "Rencontres du LYOS" (Lyon, Nov. 15, 2019) entitled : "Biomatériaux et cellules souches pour la médecine régénératrice des articulations: la route est elle encore longue?"

Aviesan - 3D culture & organoidsV. Delplace's talk - Aviesan (Paris, 2/12/2019)

Presentation of Vianney Delplace at : "Journée Aviesan - "3D culture & organoids" (Paris, Dec. 2, 2019) entitled : "Click" hydrogels as innovative tools for 3D cell culture (and more)"

Bioceramics 31Bioceramics31 award for C. d'Arros !

Congratulations to Cyril d'Arros who obtained the second place award for the oral presentation "3D moldable scaffold as a new platform for bone tissue engineering strategy with improved handling properties" !

RMeS SAB MembersVisit of the Scientfic Advisory Board (SAB)

The RMeS SAB meeeting took place on November 14th, 2019 in Nantes. Reports and projects of our two teams (ReJoint and RegOs) were presented to the members of the SAB : Profs. D. Mantovani, R. Baron & D. Mainard. Overall, SAB members were particularly impressed by our work and research facilities. Their strong expertise and advice will be highly beneficial for our present and futur projects.

New members

Charlotte PlardCharlotte Plard

Charlotte is a M2 student. She will work on mesenchymal stem cells for the treatment of osteoarthritis

She joined our unit on Jan. 13th 2020
Her supervisor is Claire Vinatier

Davy AubeuxDavy Aubeux

Davy is a PhD student. He will work on resolution of inflammation in clinical situations associated with very common conditions such as dental pulp

He will join our unit on Feb. 3th 2020
His supervisors are Valérie Geoffroy & Alexis Gaudin

C BelhoulCarine Behloul

Carine is a Pharma student. She will work on the development of a composite cement formulation for bone regeneration

She will join our unit on Feb. 3th 2020
Her supervisors are Pierre Weiss and Marie-Michèle Germaini

Feras OyounFeras Oyoun

Feras is a M2 student. He will work on REGOMIR Project

He joined our unit on Jan. 6th 2020
His supervisors are Elise Lepeltier (MINT Angers), Angélique Galvani & Valérie Geoffroy

Nathaly GaviraNathaly Gavira

Nathaly is a M2 student. She will work on comparative anatomy of IVD

She joined our unit on Jan. 2nd 2020
Her supervisors are Johann Clouet, Marion Fusellier & Cyril Decante

Clément MorinClément Morin

Clément is a M2 student. He will work on osteoporosis screening via image analysis of CBCT

He joined our unit on Jan. 6th 2020
His supervisor is Florent Autrusseau

Maxime MétayerMaxime Métayer

Maxime is a M2 student. He will work on IXBONE Project

He will join our unit on Jan. 15th 2020
His supervisors are Angélique Galvani & Pierre Guihard

PhD defense & HDR

Pierre TournierPhD Defense of Pierre Tournier

Congratulations to Pierre who defended his thesis on December 18, 2019 !

Caractérisation biologique d'une pâte osseuse allogénique pour la médecine régénératrice du squelette

Directeur de thèse: P. Weiss - Co-directeur : J. Guicheux - Co-encadrant : A. Gaudin

Leslie FrapinPhD Defense of Leslie Frapin

Congratulations to Leslie who defended her thesis on December 11, 2019 !

Ingénierie tissulaire du disque intervertébral: Développement d'un système à libération séquentielle de facteurs biologiques pour la réparation endogène du disque intervertébral humain

Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux - Co-encadrant : J. Clouet

And among other things...

General Assembly 2018

RMeS General Assemby (Campus Gavy - St Nazaire) -
May 14th, 2018

Photo Fête de Noël
Christmas Party RMeS ! December 18th, 2017

Olympiades RMES

The 2nd Edition of the RMeS "Olympiades" has taken place on Sept. 18th, 2017. 4 teams have met in good spirits. Thanks to all the participants!