Role of good oral hygiene on clinical evolution of rheumatoid arthritis: a randomized study nested in the ESPOIR cohort.

Mariette X, Perrodeau E, Verner C, Struillou X, Picard N, Schaeverbeke T, Constantin A, Ravaud P, Bouchard P

Rheumatology (Oxford). 2019 Sep 3 - Download full text

Periodontal regenerative medicine using mesenchymal stem cells and biomaterials: A systematic review of pre-clinical studies.

Portron S, Soueidan A, Marsden AC, Rakic M, Verner C, Weiss P, Badran Z, Struillou X

Dent Mater J. 2019 Sep 11 - Download full text

advanced drug delivery reviews
Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors

Frapin L, Clouet J, Delplace V, Fusellier M, Guicheux J, Le Visage C

Adv Drug Deliv Rev. 2019 Aug 21 - Download full text

Caveolae: The FAQs

Parton RG, Del Pozo MA, Vassilopoulos S, Nabi IR, Le Lay S, Lundmark R, Kenworthy AK, Camus A, Blouin CM, Sessa WC, Lamaze C

Traffic. 2019 Aug 26. - Download full text



INSERMLaunching of the INSERM French network : NetwOArk

RMES is happy to announce the launching of the INSERM French network dedicated to peripheral and spine osteoarthritis : NetwOArk. Jerome Guicheux will serve NetwOArk as national coordinator with Francis Berenbaum as a co-coordinator. NetwOArk aims bringing together all the scientific actors involved in osteoarthritis research in order to federate and promote the emergence of high-level scientific works in this field. NetwOArk is created for 4 years and is supported by INSERM, Aviesan and ITMO PMN. NetwOArk is organized around 4 work packages coordinated by Claire Vinatier and Esther Potier (WP 1 pathophysiology), Khorng Ea and Yves-Marie Pers (WP2 disease bio markers), Christelle N’Guyen and Jeremy Sellam (WP3 prevention and treatment) and David Moulin and Emeline Perrier-Groult (WP4 innovation). A first scientific event will be organized in 2020 to gather the French actors involved in Osteoarthritis research. We hope to meet you all to share recent advances in basic, translational and clinical research dedicated to this incurable and disabling disease.

bioregateNew funding of BIOREGATE

The STEP team (UMR 1229 INSERM-Nantes University-ONIRIS) is pleased to announce that the project DISCODOG was awarded of BIOREGATE (Région Pays de la Loire) grant (veterinary clinic grant). The project is led by Johann CLOUET and Marion FUSELLIER. This project will be performed in collaboration with the MINT laboratory (INSERM 1066 CNRS 6021) in Angers (Elise LEPELTIER).The two objectives of DISCODOG are to develop a new therapeutic tool to treat discogenic lumbalgia, consisting in miRNA encapsulated in lipid nanocapsules and to validate a new method to detect early signs of disc degeneration in canine patients. After intradiscal injection in clinic dogs, security and efficacy of the treatment will be followed by the mean of orthopedic and neurologic examination as well as by MRI, during 6 months. 120 k€ will be dedicated to the DISCODOG project during 2 years. The project will begin during the first semester of 2020..

FNSNF ET ANRNew funding of FNSRS & ANR

The STEP team is pleased to announce that the INDEED project (International Collaborative Research Project - PRCI) led by Matteo D'Este (AO Research Institute, Switzerland) and Christophe Helary (UMR 7574, Sorbonne University- CNRS, France) in partnership with RMeS (INSERM U1229-ONIRIS-Nantes University, France) and the Biomechanical Institute (ETH, Switzerland) has been selected for funding by the Swiss national fund for scientific research (FNSRS) and the french research agency (ANR). The main objective of INDEED is to develop a 3D model of intervertebral disc (IVD) by bio-impression. Composite inks based on hyaluronic acid and collagen will be synthesized (UMR 7574) and their interactions with IVD cells will be characterized (UMR 1229). The mechanical (ETH) and biological (ARI) properties of this bio-printed IVD will be compared to those of animal and human discs. This disc model will also be used to decipher the molecular mechanisms of disc degeneration at the origin of low back pain but also for the screening of new therapeutic agents, thus contributing to reduce the use of animal experiments.

ANRNew funding of ANR 2019

The STEP team of the INSERM U1229-RMeS laboratory is pleased to announce the recent funding of the EXCELLDISC proposal as an ANR collaborative research project. EXCELLDISC will be coordinated by Catherine Le Visage (INSERM U1229, RMeS) and will be carried out in collaboration with Florence Gazeau (MSC CNRS 7087) and Grégory Lavieu (U932, Institut Curie). EXCELLDISC will investigate whether MSC-derived extracellular vesicles (EVs) could contribute to slow down, stop or reverse intervertebral disc degeneration. .


Diego MantovaniProf. Diego Mantovani

Nanocoatings, degradable metals & 3d triple cell culture in bioreactors from collagen gel scaffolds for the innovation in reparative and regenerative medicine

CHU de Quebec Research Center, Laval University
Nov. 18, 2019, 16h00 - Amphi Ricordeau

chuCHU de Nantes/SNITEM

Journée d'information & d'échange sur les dispositifs médicaux à l'hôpital : Du laboratoire au lit du patient

November 13th, 2019, from 9h00 - Auditorium du Musée d’Arts de Nantes – 10 rue Georges-Clemenceau, 44000 Nantes


RMeS in the spotlight

Fete Science 2019Science Fair 2019

RMeS has participated in the Science fair on the theme : "Repair the Skeleton".

608 visitors were welcomed from Oct. 11th to Oct. 13th, 2019.

Visitors particularly appreciated the event and the various and clear presentations !

icrsICRS World congress, Vancouver 2019

Jérôme Guicheux has been invited to give a Key note on "Exploring Stem Cells & Biomaterials for Regenerative Medicine of Intervertebral Disc: From Clinical Data to Innovative Concepts" at the ICRS World congress that is organized in Vancouver (5-9 October 2019). ICRS is the International Cartilage Regeneration & Joint Preservation society

talk ambassy1st France-USA Stem cell Symposium, Los Angeles 2019

Jérôme Guicheux has been invited to give a talk on "Stem cells and biomaterials for spinal joint regenerative medicine : from biologically inspired concepts to clinical transfer" at the 1st France-USA Stem cell symposium that took place in Los Angeles (June 25th, 2019)

intervention rouenSNMS, Rouen 2019

Jérôme Guicheux has been invited to give a talk on stem cells and regenerative medicine: "Cellules souches et médecine régénératrice des articulations : la route est-elle encore longue ?"at the SNMS congress that took place in Rouen (June 8th, 2019)

New members

Agathe LouisyAgathe Louisy

Agathe is a M2 student. She will work on the potential involvement of IL-33 in the bone resorption associated to periodontitis.

She will join our unit on Nov. 11th 2019
Her supervisor is Alexandra Cloitre

NathanNathan Lagneau

Nathan is a PhD student. He will develop a new hydrogel-assisted cell therapy for the treatment of peripheral joint osteoarthritis.

He joined our lab on Oct. 1st 2019
He is supervised by Dr V. Delplace & Prof Y. Maugars

Mélina GeorgetMélina Georget

Mélina is a PhD student. She will study the role of senescence in osteoarthritis and explore new anti-aging strategies to treat osteoarthritis.

She joined our unit on Sept. 9th 2019
Her supervisors are Dr C Vinatier and Pr G Grimandi

PhD defense & HDR

Pierre TournierPhD Defense of Pierre Tournier

Pierre will defend his thesis on December 18, 2019, at 14.00 pm (Amphi Ricordeau)

Caractérisation biologique d'une pâte osseuse allogénique pour la médecine régénératrice du squelette

Directeur de thèse: P. Weiss - Co-directeur : J. Guicheux - Co-encadrant : A. Gaudin

Leslie FrapinPhD Defense of Leslie Frapin

Leslie will defend her thesis on December 11, 2019, at 14.00 pm (Amphi D. Escande)

Ingénierie tissulaire du disque intervertébral: Développement d'un système à libération séquentielle de facteurs biologiques pour la réparation endogène du disque intervertébral humain

Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux - Co-encadrant : J. Clouet

Photo thèse ArnaudPhD Defense of Arnaud Paré

Arnaud defended his thesis on July 11, 2019, at 14.00 pm (Amphi Ricordeau)

Rôle de l'apport du dioxygène dans la régénération osseuse en zone ischémique: application aux défauts osseux mandibulaires interrupteurs

Directeur de thèse: P. Corre - Co-directeur : Olivier Gauthier

And among other things...

General Assembly 2018

RMeS General Assemby (Campus Gavy - St Nazaire) -
May 14th, 2018

Photo Fête de Noël
Christmas Party RMeS ! December 18th, 2017

Olympiades RMES

The 2nd Edition of the RMeS "Olympiades" has taken place on Sept. 18th, 2017. 4 teams have met in good spirits. Thanks to all the participants!