ACS Biomaterials
Tailored Three-Dimensionally Printed Triply Periodic Calcium Phosphate Implants: A Preclinical Study for Craniofacial Bone Repair

Paré A, Charbonnier B, Tournier P, Vignes C, Veziers J, Lesoeur J, Laure B, Bertin H, De Pinieux G, Cherrier G, Guicheux J, Gauthier O, Corre P, Marchat D, Weiss P

ACS Biomater Sci Eng. 2020 Jan 13;6(1):553-563 - Download full text

Ultrasonography-Guided Perineural Injection of the Ramus ventralis of the 7 and 8th Cervical Nerves in Horses: A Cadaveric Descriptive Pilot Study

Touzot-Jourde G, Geffroy O, Tallaj A2, Gauthier O, Denoix JM

Front Vet Sci. 2020 Feb 25;7:102 - Download full text

Dental Educ
Educational gaming for dental students: Design and assessment of a pilot endodontic-themed escape game

Aubeux D, Blanchflower N, Bray E, Clouet R, Remaud M, Badran Z, Prud'homme T, Gaudin A

Eur J Dent Educ. 2020 Mar 6 -

NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate

Pauline Colombier, Boris Halgand, Claire Chédeville, Caroline Chariau, Valentin François-Campion, Stéphanie Kilens, Nicolas Vedrenne, Johann Clouet, Laurent David, Jérôme Guicheux, Anne Camus

Cells 2020, 9(2), 509 - Download full text


INSERMLaunching of the INSERM French network : NetwOArk

RMES is happy to announce the launching of the INSERM French network dedicated to peripheral and spine osteoarthritis : NetwOArk. Jerome Guicheux will serve NetwOArk as national coordinator with Francis Berenbaum as a co-coordinator. NetwOArk aims bringing together all the scientific actors involved in osteoarthritis research in order to federate and promote the emergence of high-level scientific works in this field. NetwOArk is created for 4 years and is supported by INSERM, Aviesan and ITMO PMN. NetwOArk is organized around 4 work packages coordinated by Claire Vinatier and Esther Potier (WP 1 pathophysiology), Khorng Ea and Yves-Marie Pers (WP2 disease bio markers), Christelle N’Guyen and Jeremy Sellam (WP3 prevention and treatment) and David Moulin and Emeline Perrier-Groult (WP4 innovation). A first scientific event will be organized in 2020 to gather the French actors involved in Osteoarthritis research. We hope to meet you all to share recent advances in basic, translational and clinical research dedicated to this incurable and disabling disease.

bioregateNew funding of BIOREGATE

The STEP team (UMR 1229 INSERM-Nantes University-ONIRIS) is pleased to announce that the project DISCODOG was awarded of BIOREGATE (Région Pays de la Loire) grant (veterinary clinic grant). The project is led by Johann CLOUET and Marion FUSELLIER. This project will be performed in collaboration with the MINT laboratory (INSERM 1066 CNRS 6021) in Angers (Elise LEPELTIER).The two objectives of DISCODOG are to develop a new therapeutic tool to treat discogenic lumbalgia, consisting in miRNA encapsulated in lipid nanocapsules and to validate a new method to detect early signs of disc degeneration in canine patients. After intradiscal injection in clinic dogs, security and efficacy of the treatment will be followed by the mean of orthopedic and neurologic examination as well as by MRI, during 6 months. 120 k€ will be dedicated to the DISCODOG project during 2 years. The project will begin during the first semester of 2020..


Fan YangProf. Fan Yang

From Zip lining to Lego building: Novel Hydrogels for Stem Cell-based Tissue Regeneration and Disease Modeling

University of Stanford
Jan 17, 2020, 14h30 - Amphi Landais (Dental Faculty)

Julien NicolasDr. Julien Nicolas

Advanced macromolecular engineering: from biodegradable vinyl materials to anticancer polymer prodrugs

Institut Galien Paris-Sud, CNRS UMR 8612
March 10, 2020, 11h00 - Amphi Ricordeau (Dental Faculty)

RMeS in the spotlight

iPSpine Consortium iPSpine in Nantes

On Jan. 29th and 30th, the consortium iPSpine (Induced pluripotent stem cell-based therapy for spinal regeneration) meeting was held in Nantes (Passage Ste Croix) and organized by RMeS team. This 5-year project falls under the European Union’s Horizon 2020 programme to fund research that improves knowledge, testing, and exploitation platforms that address the future of advanced therapies in Europe. The project is coordinated by Professor Marianna Tryfonidou at Utrecht University.

Sciences et AvenirSciences et Avenir - Interview of J. Guicheux

Interview of J. Guicheux in the latest publication of the journal "Sciences et Avenir" as part of an article on "Back pain - The methods that work"

LYOSJ. Guicheux's talk - Rencontres du Lyos (Lyon, 15/11/2019)

Presentation of Jérôme Guicheux at : "Rencontres du LYOS" (Lyon, Nov. 15, 2019) entitled : "Biomatériaux et cellules souches pour la médecine régénératrice des articulations: la route est elle encore longue?"

Aviesan - 3D culture & organoidsV. Delplace's talk - Aviesan (Paris, 2/12/2019)

Presentation of Vianney Delplace at : "Journée Aviesan - "3D culture & organoids" (Paris, Dec. 2, 2019) entitled : "Click" hydrogels as innovative tools for 3D cell culture (and more)"

New members

Gaetan LutzweilerGaëtan Lutzweiler

Gaëtan is post-doctoral researcher. He will work on Cardiogel project and will develop hydrogels to reconstruct bone tissue in collaboration with Institut du Thorax

He will join our unit on May 1st 2020
His supervisor is Pierre Weiss

Charlotte FosseCharlotte Fosse

Charlotte is in engineering school. She will work on GAG-enriched click microgels for cell encapsulation and OA treatment

She will join our unit on April 1st 2020
Her supervisor is Vianney Delplace

Floriane EtienneFloriane Etienne

Floriane is clinical research assistant. She will work on Discodog and IPSPine projects

She joined our unit on March 2nd 2020
Her supervisors are Marion Fusellier & Johann Clouet

Fatima FneichFatima Fneich

Fatima is post-doctoral researcher. She will work on 3D printing

She joined our unit on March 2nd 2020
Her supervisor is Pierre Weiss

PhD defense & HDR

Sarah BeckHDR of Sarah Beck

Sarah will defend her HDR on April 23, 2020 at 2.00 pm (Amphi Ricordeau)

Pierre TournierPhD Defense of Pierre Tournier

Congratulations to Pierre who defended his thesis on December 18, 2019 !

Caractérisation biologique d'une pâte osseuse allogénique pour la médecine régénératrice du squelette

Directeur de thèse: P. Weiss - Co-directeur : J. Guicheux - Co-encadrant : A. Gaudin

Leslie FrapinPhD Defense of Leslie Frapin

Congratulations to Leslie who defended her thesis on December 11, 2019 !

Ingénierie tissulaire du disque intervertébral: Développement d'un système à libération séquentielle de facteurs biologiques pour la réparation endogène du disque intervertébral humain

Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux - Co-encadrant : J. Clouet

And among other things...

General Assembly 2018

RMeS General Assemby (Campus Gavy - St Nazaire) -
May 14th, 2018

Photo Fête de Noël
Christmas Party RMeS ! December 18th, 2017

Olympiades RMES

The 2nd Edition of the RMeS "Olympiades" has taken place on Sept. 18th, 2017. 4 teams have met in good spirits. Thanks to all the participants!