BIOREGATE European Forum 2018 Bioregate Forum

December 12-14, 2018 - Nantes

ROAD Network Winter School 2018
Programme Ecole Road

6 & 7 Dec 2018 - Paris
Organized by the Réseau ROAD.

ANRANR Research Grants

A triple success for the INSERM-Nantes University-ONIRIS UMRS 1229-RMeS laboratory at the 2018 call for proposal of the French national research Agency (ANR) as coordinator. The STEP team is pleased to announce the funding of two novel projects, PPAROA and KLOTHOA. PPAROA is an ANR collaborative research project (PRC) that will be coordinated by Jerome Guicheux (INSERM UMRS 1229-RMeS). PPAROA will aim to define the role of the nuclear Peroxisome Proliferator-Activated Receptor (PPAR) beta/delta in the anti-osteoarthritic and immunomodulatory properties of adult mesenchymal stem cells. In partnership with the Christian Jorgensen’s Laboratory (INSERM UMRS 1183-IRMB, University of Montpellier), the PPAROA project will be supported by the ANR for 4 years. KLOTHOA is an ANR young researchers (JC/JC) project that will be coordinated by Claire Vinatier (INSERM UMRS 1229-RMeS). KLOTHOA will aim to define the role of the anti-aging protein Klotho in the onset of osteoarthritis and whether modulating the expression of Klotho by adeno-associated virus-mediated gene therapy may help identify novel anti-osteoarthritic treatments. The KLOTHOA project will be supported by the ANR for 3 years. The REGOS team is also pleased to announce the funding of an industrial collaborative research project. The IXBONE project, coordinated by Pierre Weiss (INSERM UMRS 1229-RMeS) will aim to define new bone regeneration strategies for the treatment of mandibular osteoradionecrosis using mesenchymal stem cells and innovative biomaterials. In partnership with the French Institute for Radiological Protection and Nuclear Safety (IRSN, Fontenay aux Roses, Noëlle Mathieu) and the French Organ, Tissue, Regeneration, Repair and Replacement company (OTR3, Paris, Denis Barritault), the IXBONE project will be supported by the ANR for 4 years.  

Fondation AvenirFondation de l'Avenir Research Grant

The STEP team is pleased to announce the funding of the CAPSTEM project by the Fondation de l’Avenir pour la Recherche Médicale Appliquée. CAPSTEM will be coordinated by Catherine Le Visage in collaboration with Claire Vinatier and Jerome Guicheux from RMeS laboratory, Denis Renard from the BIA laboratory (INRA UR 1268, Nantes) and Anne Des Rieux from the Louvain Drug Research Institute (LDRI, Louvain, Belgium). CAPSTEM will aim to determine whether encapsulating mesenchymal stem cells in hydrogel-based microcapsules may help exploit their anti-osteoarthritic properties. The CAPSTEM project is funded for 2 years and will be conducted in the framework of Audrey Smith’s PhD Thesis.

Pauline ChichiriccoPhD Defense of Pauline Chichiricco

Pauline Chichiricco defended her thesis on November 26, 2018, at 10.00 am (Amphi Ricordeau, Dental Faculty)

Interpenetrating polymer networks hydrogels of silanized hydroxypropylmethyl cellulose/methacrylated polysaccharides for biomedical applications

Directeur de thèse: P. Weiss - Co-directeurs : X. Struillou et C. Jérôme (Liège University)

Le Club des Belles Souris 2018
Club des Belles Souris

22 Nov 2018 - Nantes



Symposium "RNA interference to promote tissue regeneration" during 5th Termis World Congress (Session 68)

Organized by Sing Yian CHEW,Singapour and V. Geoffroy
on September 7th, 2018
Kyoto International Conference Center, Kyoto, Japan - Sept. 4-7, 2018


Dr. Johnna TemenoffDr. Johnna Temenoff

GAG-based Biomaterials to Address Tissue Degeneration after Rotator Cuff Tendon Tears

Georgia Tech/Emory University
July 3rd, 2018, 14.00h - IRS UN - Amphi D. Escande






The next DEVSTEM club took place on Nov. 6, 2018 at 10.00 am in the School of dental Surgery (Amphi Landais). Presentations of E. Loffet and Z. Reda Al Sayed

NexTNexT Initiative Research Grant

The STEP team is pleased to announce the funding of the SHELBY project by the NEXT initiative of the Nantes University (Internal Interdisciplinary Projects). SHELBY will be coordinated by Catherine Le Visage in collaboration with Claire Vinatier and Jerome Guicheux from RMeS laboratory, Denis Renard from the BIA laboratory (INRA UR 1268, Nantes) and Arnaud Tessier from the CEISAM laboratory (UMR CNRS 6230, Nantes). SHELBY will aim at developing a new generation of functionalized boronic acid hydrogels with self-healing properties and evaluating their ability to encapsulate mesenchymal stem cells and prevent osteoarthritis. The SHELBY project is funded for 1 year with possible extension up to 4 years and will be developed in the framework of Fabien Nativel’s PhD Thesis.

Marie Michèle GermainiMarie-Michèle Germaini

Marie-Michèle is post-doc. She will work on 3D biomimetic 3D printing cement for personalized repair of alveolar cleft. She will work on printable formulation of calcium phosphate cement using hydrogels in collaboration with GPEA, LS2N and INRA. She is implicated in the bioregate 3D refentine program coordinated by Pierre Corre. The objective is building adapted 3D bone scaffold for children with cleft palate.

She joined the REGOS team on Oct. 1st 2018

Lara FigueiredoCongratulations to Lara Figueiredo !

Lara Figueiredo defended her thesis on September 17, 2018, at 2.00 pm (Amphi Ricordeau, Dental Faculty)

3D biomimetic matrices to design in vitro stem cell niches

Marianne LafontMarianne Lafont

Marianne is Engineer. She will work on ANR program GELIHPARBAL in collaboration with Jérome Sohier in Lyon. She will characterize new elastic hydrogels for muscle Tissue Engineering

She will join the REGOS team on Sept. 17 2018

Vianney DELPLACEVianney Delplace

Vianney is post-doc
He will work on the development of injectable and self-healing hydrogels for the delivery of cells and/or molecules.

He will join the STEP team on Sept. 10 2018

Gaël RochefortGaël Rochefort

Gaël (PhD-HDR) is Maturation Research Engineer from SATT Ouest Valorisation affected to RMeS. He will work on Cardiogel project in collaboration with Institut du Thorax

He will join the REGOS team on Sept. 3 2018

Pierre GuihardPierre Guihard

Pierre Guihard (PhD) is associated-Professor at the school of dental medicine of Nantes university. His project is aimed at characterizing the coordinated role of Matrix Gla protein and PiT transporters in regulating bone homeostasis

He will join the STEP team on Sept. 1 2018


Magazine INSERM CouvArticle "Magazine de l'INSERM - Les dents, miroir de notre santé ?

Publication of a journal article in "Magazine de l'INSERM" (Edition of July 2018)
Les dents, miroir de notre santé ?
Download full text

Nora BouhsinaNora Bouhsina

Nora is a PhD student
She will work on Regenerative medicine of intervertebral disc : from stem cells and biomaterials to novel imaging technology

She will join the STEP team on Sept. 1, 2018

Her supervisor is J. Clouet

Sylvie BeaufilsPhD Defense of Sylvie Beaufils

Sylvie Beaufils will defend her thesis on August 27, 2018, in Reims

Synthèse électrochimique et caractérisation de nanoparticules d’hydroxyapatite, mise en charge de matrices extracellulaires d’hydrogel et leurs caractérisations mécaniques et biologiques

Directeur de thèse: P. Millet (Reims University)

Xavier PrieurXavier Prieur, PhD

Déficience en Seipine, de la dysfonction adipocytaire aux risques cardiovasculaires

UMR_S 1087 / UMR_C 6291
January 19th, 2018, 13h - Meeting Room RMeS

Nina BonNina Bon

Nina is a research engineer
She will work on the AdipOS project leaded by Sarah Beck

She joined the STEP team on June 1, 2018

Alexis GaudinAlexis Gaudin

Alexis is MCU/PH
He works on regulation of immune response related to pulp and periodontal disease & inflammation in tissue repair and regeneration related to oral cavity

He joined the REGOS team on Feb. 15, 2018

BioregateAward for GENOA project

We are pleased to announce that the GENOA project "Gene therapy for osteoarthritis: controlled expression of anti-geronic factors" headed by Claire Vinatier in the STEP team is laureate of the call for proposal 2018 of the BIOREGATE regenerative medicine cluster funded by the region Pays de la Loire. GENOA will receive a 3-year fellowship for a PhD student and substantial funds for covering scientific experiments as well as valorization and dissemination activities. GENOA will be conducted in collaboration with Oumeya Adjali, head of the translational gene therapy for genetic diseases laboratory (INSERM UMR 1089, Nantes). GENOA will aim at (i) deciphering the role of the anti-geronic factor KLOTHO in the onset of osteoarthritis (ii) determining whether the adeno-associated virus-mediated intraarticular overexpression of this protein may help control disease progression in murine models  

Pauline ChichiriccoPauline's Prize - BPG 2018

Pauline Chichiricco received an award for the best oral presentation at the BPG Conference (Belgian polymer group) held on 28-29 May 2018 in Blankenberge, Belgium. Pauline presented her third year thesis on the Photo-crosslinkable hydrogel for Guided Periodontal Tissue Regeneration . Congratulations Pauline !


Agence BiomedecineAward for PPAROA Project

We are pleased to announce that the PPAROA project "Improvement of the therapeutic effect of CSM in osteoarthritis: Role of PPAR b/d" headed by C. Vinatier & J. Guicheux in the framework of B. Bodic's PhD thesis is laureate of the call for proposal 2018 "research & transplantation " from the French biomedicine agency. This project, selected from 90 proposals, will receive 30,000 € and will be conducted in collaboration with the INSERM UMR 1183-IRMB (F. Djouad & C. Jorgensen, Montpellier).

Photo Gwenola Touzot JourdePhD Defense of Gwenola Touzot-Jourde

Gwénola defended her thesis on January 25, 2018

Injections péri-neurales écho-guidées du rameau ventral du 7ème et 8ème nerf spinal cervical chez le cheval sain : étude anatomique post-mortem et évaluation clinique de l'anesthésie tronculaire

Directeur de thèse: O. Gauthier - Co-directeurs: J.M. Denoix et O. Geffroy

Lily PaillatLily Paillat

Lily is a PhD student.
She works on "Caveodisc project".
She joined the STEP team on Feb. 8, 2018

Her supervisor is A. Camus

Denis WaastDenis Waast

Denis Waast is Clinician
He works in orthopaedic service in Nantes Hospital
He joins the STEP team on Feb. 1, 2018

His medical interest is osteoarthritis

Prix Julia SFBTMGiulia's Prize - JFBTM 2018

Giulia Frangi received an award for her oral presentation at the Journées Françaises de Biologie des Tissus Minéralisés held on 21, 22 and 23 March 2018 in Monaco. Giulia presented her first year thesis on the analysis of the dialogue between the skeleton and adipose tissue. Congratulations Giulia!


Alexandra CloitreCongratulations to Alexandra Cloitre

RMES is proud to announce that Dr Alexandra Cloitre (DDS-PhD candidate) has been appointed university/hospital scientist lecturer and practitioner (MCU-PH, tenured position) in the oral surgery department of the Nantes University Hospital (Prof. P. Lesclous) and School of Dental Medicine


Photo Zahi BadranCongratulations to Zahi Badran

RMES is proud to announce that Dr Zahi Badran (MCU-PH) has been promoted as full professor (PU-PH, tenured) in the Periodontology department of the Nantes University Hospital and School of Dental Medicine (Prof A. Soueidan)



DEVSTEM club was held on Feb. 6, 2018 in the School of dental Surgery

Presentations of B. Halgand and M. Charrier

Hilel MoussiHilel Moussi

Hilel is a PhD student.
She works on " Life foam cement ".
She joins the REGOS team on Jan. 19, 2018

Her supervisors are H. Gauthier & J. Le Bideau

Photo Zahi BadranHDR of Zahi Badran

Zahi defended his HDR on February 9, 2018


Foreum The STEP team welcomes the selection of the SENOA project to identify the role of senescence in osteoarthritis and its potential targeting for the treatment of this disease. This project is supported for 600 K€ by the Foundation for Research in Rheumatology (FOREUM, Switzerland) of the European League Against Rheumatism (EULAR).
Claire Vinatier will be in charge of the coordination of the working group n ° 2 with the objective of characterizing senescence and the associated molecular mechanisms in osteoarthritic joints.

5th edition of «Stem cells, pluripotence & development»  - March 1st 2018, from 1.30 pm (Amphi D. Escande, IRS).

Programme Cellules Souches
Programme Cellules Souches

Mobility offer / offre de mobilité on BIO3 platform
This offer is intended exclusively for Inserm agents (civil servants and permanent employees) who are active or in the process of reinstatement.

We are looking for a Research Assistant / Ingénieur d'Etudes with the following skills :

- Biology: cell culture, cyto-compatibility assays (viability, proliferation, apoptosis, differentiation)
- Microscopy: confocal imaging of fluorescent molecules and cells, 3D reconstruction 3D
- Biomecanics: dynamic compressions assays, rupture assay

Ingénieur-e en techniques biologiques - BAP A - Biologie et santé, Sciences de la vie et de la terre
Obtenir le texte de l'offre: télécharger ici

Offre également disponible sur le site de l'Inserm 



Marie DemayMarie B. Demay, MD

Phosphate Regulation of Bone Formation and Marrow Adipose Tissue

Massachusetts General Hospital
December 8th, 2017, 11h - Amphi Ricordeau

SoleneSolene TEISSIER

Solène is working as a Research Assistant in the REGOS team

Her supervisor is V. Geoffroy

Lucile FigueresLucile Figueres

Lucile is chief resident in Nantes hospital (Dpt of Nephrology). She joins the STEP team

Her supervisors are L. Beck & J. Guicheux

Nina BonCongratulations to Nina Bon !

Nina defended her thesis on Dec. 8th, 2017

Etude du rôle des protéines PiT1/Slc20a1 et PiT2/Slc20a2 dans la détection du phosphate extracellulaire dans le squelette des mammifères

Directeur de thèse: L. Beck - Co-encadrant  : S. Beck

ElodieCongratulations to Elodie Le Tilly !

Elodie defended her thesis on December 20, 2017

Homéostasie du cartilage articulaire lors de l’arthrose liée au vieillissement : étude des rôles de la protéine Klotho et d’un cocktail de molécules anti-oxydantes

Directeur de thèse: L. Beck - Co-encadrant : C. Vinatier

FahdCongratulations to Fahd Hached !

Fahd defended his thesis on December 13, 2017

Encapsulation de cellules stromales mésenchymateuses humaines dans des hydrogels polysaccharidiques :potentiel application dans le traitement de l'arthrose

Directeur de thèse: G. Grimandi - Co-encadrants : A. Billon-Chabaud & C. Vinatier

Photo T. HocThierry Hoc

Biomécanique à différentes échelles des tissus ostéoarticulaires sains et pathologiques

Ecole Centrale de Lyon
October 18th, 2017, 14h - IRS-UN

Michael Ragunath
Michael Raghunath
Macromolecular crowding: Boosting the formation of an extracellular matrix microenvironment in vitro

Zurich University of Applied Sciences
July 6, 2017, 14h - IRS-UN

Workshops & symposia

Workshop EVs
Extracellular Vesicles in Therapeutics and Healthy Diet Workshop

Organized by B. Kaeffer and V. Geoffroy
Jounées Scientifiques de l'Université de Nantes

June 2, 2017 - Congress Center


Society for Biohydrogels symposia

Organized by P. Weiss and C. Le Visage

TERMIS European Chapter Meeting 2017

June 26 and June 18, 2017 - Davos Congress Center

Couverture ça m'intéresse Publication of a journal article in "ça m'intéresse" (Edition of Sept. 2017)
Interview of Dr. J. Guicheux

Patrick Saulnier
Nanomedecines, des solutions pour améliorer la biodisponibilité d'actifs thérapeutiques ou (et) diagnostiques

U1066 MINT, Université d'Angers
May 22, 2017, 11h - Ricordeau

Programme Folles Souris
Journée Folles Souris

This club gathers French scientists to promote animal models.

Congratulations to

Benoit Bodic and Giulia Frangi for their PhD scholarships (from Nantes Biology doctoral school for Giulia) ! They will join our lab on Sept. 2017, for 3 years.

Nina Henry
PhD Defense - Nina Henry
Médecine régénératrice du disque intervertébral
Développement de biomatériaux pour la libération prolongée de facteurs de croissance

Directeurs de thèse: J. Guicheux et J. Le Bideau
July 20, 2017, 14h30 - UFR Odontologie, Amphi Ricordeau

BBC meeting
"BBC meeting"
5-6 Oct 2017 - Nantes

The BBC meeting is devoted to bone and cartilage, with a special emphasis on basic research.

Photo Laure
PhD Defense - Laure Meramedjian

December 16, 2016, 14h30 - UFR Odontologie, Amphi Ricordeau