Personnel d'un organisme de recherche


INSERM research director/Professor. Director INSERM U1229, RMeS, Regenerative Medicine and skeleton research Lab. Head Team STEP "skeletal physiopathology and joint regenerative medicine". Nantes University Hospital. Scientific director, SC3M “Electron Microscopy, Microcharacterization and Functional Morphohistology-imaging Core Facility » platform, UMS INSERM 016, CNRS 3556/FED 4203, François Bonamy Health Federative Research Institute. President, the French Society of Mineralized Tissue Biology (SFBTM). National Coordinator, the French Osteoarthritis network “ROAD”. Board of directors, The osteoarthritis research society international (OARSI).


1 place Alexis ricordeau, 44042 Nantes Cedex 1, France

0240412919 (n° interne : 312919)
Site internet

Discipline(s) enseignée(s)

Tissue engineering
Regenerative medicine
Physiopathology of osteoarticular tissues
Biology of stem cells

Thèmes de recherche

The skeleton is affected by a large number of diseases originating from developmental abnormalities, growth impairment, repair dysfunction, cancer and age-associated loss of function. Among these diseases, I am particularly interested in deciphering the pathogenic mechanisms of degenerative age-associated cartilage diseases including osteoarthritis (OA) and the disc degenerative disease also named discarthrosis (DA). I focus my attention on the role of anti-aging factors, autophagy and senescence in the onset of OA and DA. Thanks to the use of animal models closely mimicking the human disease, we are also trying to identify novel therapeutic targets. Due to the increasing clinical situations where cartilaginous tissues are lost (traumatic defects, congenital diseases..) or compromised (osteoarthritis, discarthrosis..), I am also involved in the development of research programs based on the use of stem cells (mesenchymal and induced pluripotent) and hydrogels for the development of joint-targeting drug delivery systems and cell-based regenerative therapeutics.
Key words: Skeleton, osteoarthritis, disc degenerative disease, stem cells, regenerative medicine, hydrogels, biomaterials-assisted cell therapy.


Activités / CV

Jérôme Guicheux (48 yo) has received his B.S. degree in cell biology and pathophysiology in 1992, his doctorate (PhD) in Biomaterials, cell biology and health sciences in 1997 and his habilitation for directing research (HDR-Habilitat) in 2002 at the University of Nantes. He studied the biology of skeletal cells with Professors Bonjour and Caverzasio at the University Medical Center of Geneva (Switzerland ) as a postdoctoral researcher (1997-1999). He completed his post- doctoral research as a research associate in the laboratory of Professor Gabay in the rheumatology department of the University Hospital of Geneva (1999-2000). He joined the University of Nantes and INSERM as a research associate (CR2 Inserm, tenured) in 2001. He was then promoted Inserm research director (DR2)/Professor in 2009 and was an associated-Professor at the national veterinary school of Nantes (2006-2010); He has been appointed (january 2017) director of the INSERM research Lab UMR 1229 (RMES, « regenerative medicine and skeleton », Nantes, France, 90 staff members) and head of the STEP (skeletal physiopathology and joint regenerative medicine) team (35 staff members).

JG has served (2011-2016) as a deputy director of the François Bonamy Health Federative Research Institute (UMS INSERM-CNRS 016/ FED 4203 ; formerly IFR26) (900 staff members). He is an elected-member of the steering committee of the Nantes college of Dentistry, and appointed member of the strategic research committee (CRS) and biomedical research and public health committee (CRBSP) of the Nantes University Hospital (NUH). He is also an appointed member of the scientific council of the Nantes school of medicine. He is a member of the Board of Directors and President of the French society of mineralized tissue biology (SFBTM). JG also served (2014-2017) as the scientific Director of “Arthritis R&D”, spin-off from the “Arthritis Foundation” (non-profit and public interest association). He coordinates the first French national network of the Arthritis Foundation dedicated to Osteoarthritis and joint aging (7 labs and affiliated hospitals). He is the recipient of more than 80 public and private research contracts. He has coordinated 4 pluri-annual research programs of the French national research agency (ANR) dedicated to stem cells and regenerative medicine. In 2011, he received the “Victor and Erminia Mescle Price” awarded by the French Foundation for Medical Research (FRM) for his work on regenerative medicine. In 2012, he was awarded recipient of a hospital contract for translational research (CHRT) with NUH and receives the “scientific excellence award” from INSERM (2010-2015). In 2016, JG has received the innovation award from the arthritis foundation for his work on cartilage regeneration. 

Scientific activities (1 january 2018)

  • PubMed: 153 listed publications.
  • ISI web of knowledge Researcher ID: F-7767-2013
  • 84 invited lectures.
  • 8 patents

Editorial activities
2016-… “Editorial Board member” of Current stem cell research and therapy
2013-… "Senior editorial board member " of the American Journal of Stem cells.

2011-… “Academic editor” of PlosOne.