Frédéric BLANCHARD

Precision medicine in rheumatoid arthritis, doctoral school of Biology-Health of Nantes (for medical and thesis students).

Bone and joint, chronic inflammatory rheumatisms, tendinopathy, patient cohorts, macrophages, stromal cells, cytokines, scRNAseq, spatial multi-omics, cell communication

2022: Research Director, RMeS UMR1229, Nantes, France.
2014: Research Director, PhyOs UMR1238, Nantes, France.
2005: Tenured Researcher (CR1), LPRO UMR957, Nantes, France.
2002: Postdoc, CRCINA Inserm U601 and LPRO UMR957, Nantes, France
2002: Habilitation to Direct Research (HDR), Nantes University
1999: Postdoc, Roswell Park Cancer Institute, Buffalo, NY, USA.
1998: PhD in Health research, CRCINA Inserm U463, Nantes University, France.

Researcher ID (web of science) : K-8018-2015
ORCID : https://orcid.org/0000-0003-1055-2573
Main publications

• De Lima J, Boutet MA, Bortolotti O, Chépeaux LA, Glasson Y, Dumé AS, Lau R, Humbert P, Allain S, Le Pluart A, Nerviani A, Fossati-Jimack L, Michaud HA, Guicheux J, Le Goff B, Lewis MJ, Pitzalis C, Courties G, Apparailly F, Blanchard F. Spatial mapping of rheumatoid arthritis synovial niches reveals a LYVE1+ macrophage network associated with response to therapy. Ann Rheum Dis. 84:1955-1967, 2025.
• Humbert P, Vialle C, Chevalerias M, Crenn V, Waast D, Boutet MA, Blanchard F, Le Goff B. Targeting the Colony-Stimulating Factor 1 axis for the treatment of Tenosynovial Giant Cell Tumors. Cytokine Growth Factor Rev. 86:137-48, 2025.
• Hascoët E, Blanchard F, Blin-Wakkach C, Guicheux J, Lesclous P, Cloitre A. New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis. Bone Res. 11:26, 2023.
• Boutet MA, Courties G, Nerviani A, Le Goff B, Apparailly F, Pitzalis C, Blanchard F. Novel insights into macrophage diversity in rheumatoid arthritis synovium. Autoimmun Rev. 20:102758, 2021.
• Herman J, Le Goff B, De Lima J, Brion R, Chevalier C, Blanchard F, Darrieutort-Laffite C. Pro-inflammatory effects of human apatite crystals extracted from patients suffering from calcific tendinopathy. Arthritis Res Ther. 23:131, 2021.
• Najm A, Masson FM, Preuss P, Georges S, Ory B, Quillard T, Sood S, Goodyear CS, Veale DJ, Fearon U, Le Goff B, Blanchard F. miR-17-5p reduces inflammation and bone erosions in collagen induced arthritis mice and directly targets the JAK-STAT pathway in rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheumatol. 72:2030-2039, 2020.
• Darrieutort-Laffite C, Arnolfo P, Garraud T, Adrait A, Couté Y, Louarn G, Trichet V, Layrolle P, Le Goff B, Blanchard F. Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner. J Clin Med. 8:1544, 2019.
• Humbert P, Brennan MÁ, Davison N, Rosset P, Trichet V, Blanchard F, Layrolle P. Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration. Front Immunol. 10:663, 2019.
• Garraud T, Harel M, Boutet MA, Le Goff B, Blanchard F. The enigmatic role of IL-38 in inflammatory diseases. Cytokine Growth Factor Rev. 39:26-35, 2018. 
• Boutet MA, Najm A, Bart G, Touchais S, Trichet V, Layrolle P, Gabay C, Palmer G, Blanchard F, Le Goff B. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. Ann Rheum Dis. 76:1304-12, 2017.
• Boutet MA, Bart G, Gahier M, Amiaud J, Brulin B, Charrier C, Morel F, Lecron JC, Rolli-Derkinderen M, Bourreille A, Vigne S, Gabay C, Palmer G, Le Goff B, Blanchard F. Distinct Expression of IL-36a, b, g, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease. Clin Exp Immunol, 184:159-73, 2016.
• Flanagan-Steet H, Aarnio M, Kwan B, Guihard P, Petrey A, Sahu S, Haskins M, Blanchard F, Steet R. Cathepsin-Mediated Alterations In TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. J Bone Miner Res, 31:535-48, 2016.
• Bougault C, Briolay A, Boutet MA, Pilet P, Delplace S, Le Goff B, Guicheux J, Blanchard F, Magne D. Wnt5a is expressed in spondyloarthritis and exerts opposite effects on enthesis and bone in murine organ and cell cultures. Transl Research, 166:627-38, 2015.
• Guihard P, Boutet MA, Brounais-Le Royer B, Gamblin AL, Amiaud J, Renaud A, Berreur M, Rédini F, Heymann D, Layrolle P, Blanchard F. Oncostatin M, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol, 185:765-75, 2015.
• Guihard P, Danger Y, Brounais B, David E, Brion R, Delecrin J, Richards CD, Chevalier S, Rédini F, Heymann D, Gascan H, Blanchard F. Induction of osteogenesis in mesenchymal stem cells by activated monocytes / macrophages depends on Oncostatin M signaling. Stem Cells. 30:762-72, 2012.