Catherine LEVISAGE

Research Director INSERM (DR2) / Deputy Head Inserm U1229 - Regenerative Medicine and Skeleton (RMeS)

Contact details

INSERM UMR 1229, Regenerative Medicine and Skeleton, RMeS, School of Dental Surgery, University of Nantes, 1 Place Ricordeau - 44300 Nantes France

Phone
0240412984 (n° interne : 312984)
Email
Catherine.Levisage@univ-nantes.fr
Personal Website
http://www.rmes.univ-nantes.fr/

Research topics

Hydrogel and joint microenvironment

To reproduce the complex 3 dimensional (3D) microenvironment experienced by cells in vivo, we have selected hydrogels, i.e complex networks of hydrophilic crosslinked polymers, for their similarity with the extracellular matrix of tissues. Our research is focused on natural, bioresorbable and non-immunogenic polysaccharides that are already commercialized for medical applications. We investigate hydroxypropyl methylcellulose (cotton) and pullulan (yeast fermentation) to design innovative hydrogels with tunable porosity and network diffusion parameters. Using various fabrication techniques, we develop chemically cross-linked hydrogels with complex architectures, tunable viscoelasticity and desired ability to mediate cellular activities through the spatial and temporal presentation of biological cues. We investigate hydrogels as i) tools for stem cell-based organogenesis and ii) carriers of cells or bioactive molecules for bio-inspired delivery strategies in cartilage and intervertebral disc regeneration.

Activities / Resume

Online CV
 

2017-

Deputy Director. Regenerative Medicine and Skeleton (RMeS) Laboratory, Nantes, France

2012-

Research Director. National Institute of Health and Medical Research, Nantes, France

2007-2012      

Senior Research Scientist. National Institute of Health and Medical Research, Paris, France

2005-2007      

Young Investigator Fellow. National Institute of Health and Medical Research, Paris, France

2003-2005      

Research Associate. Biomedical Engineering Dept, Johns Hopkins, Baltimore, USA

2000-2003      

Postdoctoral position. Biomedical Engineering Dept, Johns Hopkins - Advisor: Pr. K. Leong

1996-1999        

Ph.D. Student. University Paris 11, Paris, France - Advisor: Pr. P. Couvreur 

 

Additional informations

Recent publications
M. Gluais, J. Clouet, M. Fusellier, C. Decante, C. Moraru, M. Dutilleul, J. Veziers, J. Lesoeur, D. Dumas, J. Abadie, A. Hamel, E. Bord, S. Y. Chew, J. Guicheux, C. Le Visage
Biomaterials, 2019, 205: 81-93
 
J. Clouet, M. Fusellier, A. Camus*,C. Le Visage*, J. Guicheux
Advanced Drug Delivery Reviews, 2018,
 
L. Figueiredo, R. Pace, C. D'Arros, G. Réthoré, J. Guicheux, C. Le Visage*, P. Weiss*
Journal of Tissue Engineering and Regenerative Medicine, 2018, 12(5): 1238-1246
 
K. Flégeau, R. Pace, H. Gautier, G. Rethore, J. Guicheux, C. Le Visage*, P. Weiss*
Advances in Colloid and Interface Science, 2017, 247:589-609
 
N. Henry, J. Clouet, A. Fragale, L. Griveau, C. Chédeville, J. Véziers, P. Weiss, J. Le Bideau, J. Guicheux*, C. Le Visage*
Drug Delivery, 2017, 24(1): 999-1010 -  Full text available
 
N. Henry, J. Clouet, J. Le Bideau, C. Le Visage*, J.Guicheux*
Biotechnology Advances, 2017, 36(1): 281-294