Marine Drugs
Microcarriers Based on Glycosaminoglycan-Like Marine Exopolysaccharide for TGF-β1 Long-Term Protection

Agata Zykwinska, Mélanie Marquis, Mathilde Godin, Laëtitia Marchand,Corinne Sinquin, Catherine Garnier, Camille Jonchère, Claire Chédeville, Catherine Le Visage, Jérôme Guicheux, Sylvia Colliec-Jouault and Stéphane Cuenot

Mar. Drugs 2019, 17(1), 65 - Download full text

Scientific reports
Heparan Sulfate Mimetics: A New Way to Optimize Therapeutic Effects of Hydrogel-Embedded Mesenchymal Stromal Cells in Colonic Radiation-Induced Damage

Lara Moussa, Christelle Demarquay, Gildas Réthoré, Mohamed Amine Benadjaoud, Fernando Siñeriz, Girish Pattapa, Jérôme Guicheux, Pierre Weiss, Denis Barritault & Noëlle Mathieu

Scientific Reportsvolume 9, Article number: 164 (2019) - Download full text

Eur J Appl Physiol. 2019 Jan 4
Jumper's knee mechanical consequences in professional basketball players: the "Camel's Back curve"

Dauty M, Menu P, Garraud T, Mesland O, Berlivet T, Metayer B, Fouasson-Chailloux A

Eur J Appl Physiol. 2019 Jan 4

Hospital production cost of transcranial direct current stimulation (tDCS) in the treatment of depression

Sauvaget A, Tostivint A, Etcheverrigaray F, Pichot A, Dert C, Schirr-Bonnais S, Clouet J, Sellal O, Mauduit N, Leux C, Cabelguen C, Bulteau S, Riche VP

Neurophysiol Clin. 2018 Nov 27 - Download full text

Post-doc position on notochordal differentiation and stem cell-based therapy for intervertebral disc degeneration (starting from March 2019)

We recruit

A 24 months-postdoctoral position (funded by H2020 European research project iPSPINE,Coord. Marianna Tryfonidou, The Netherlands) working on iPS differentiation and regenerative medicine is available, starting from March 2019 in our research lab. Human iPSC maintenance and production will be performed in close collaboration with the DeviPS core facility (SFR François Bonamy, INSERM UMS 016, Nantes University), which is coordinated by the Dr. Laurent David (a specialist of somatic cell reprogramming, MCU-PH and coordinator of the platform). Selected candidate will work under the supervision of Dr Anne Camus, leader of “Stem Cells and Axial Skeleton Development” project in the team “skeletal physiopathology and joint regenerative medicine” headed by Jerome Guicheux. Applicants are invited to send a CV with skills and complete list of publications, a cover letter including a brief statement of past scientific experiences, achievements, name and email address of 2-3 references to Anne CAMUS, Jerome GUICHEUX and Laurent DAVID. Our job offer can be downloaded here !


nextI-site NExT Award for Vianney Delplace

Recently awarded a postdoctoral fellowship by the French Foundation for Medical Research (FRM), Vianney Delplace has obtained a 3-year financial support of 500 K€ from the i-site NExT (Nantes Excellence Trajectory) program, as a « junior talent ». Starting his own group within the RMeS Lab (INSERM 1229), Vianney will develop innovative hydrogel-based strategies for cartilage repair. Welcome on board, Vianney!

Leslie AwardBioregate Award for Leslie Frapin

Congratulations to Leslie Frapin who obtained the Bioregate Award for the best oral presentation "Young Researcher" for her talk entitled : "Controlled release of biological factors for progenitor cell-mediated endogenous repair of intervertebral discs".

Prix Fondation ArthroseTilman Award for Benoit Métayer

Congratulations to Benoit Metayer who obtained the Osteoarthritis Foundation Tilman Award for his work entitled : "Development of an osteoarthritis model in humanized mice to study the therapeutic effects of encapsulated human mesenchymal stem cells".

H2020An additional Horizon 2020 European research grant for INSERM UMR 1229-RMeS towards treating chronic back pain

In 2016, the European commission invested 5.5 millions Euros in the RESPINE project to clinically address whether bone marrow-derived mesenchymal stromal cells may help solve low back pain that affects hundreds of millions of patients worldwide. The double blind phase 2b RESPINE clinical trial (P.I. Christian Jorgensen, Montpellier University Hospital; EudraCT 2017-002092-25) is now recruiting more than 100 patients in France and European countries. Jerome Guicheux (Nantes scientific coordinator, STEP Team, INSERM UMR 1229-RMeS) is a task leader in this project in charge of developing cutting-edge potency assays for the preclinical evaluation of the regenerative potential of stem cells (Cécile Boyer). Fifteen patients will be recruited at the Nantes University Hospital in the department of neurotraumatology and neurosurgery (Eric Bord). After the successful funding of RESPINE, the STEP team of the INSERM UMRS 1229-RMeS is now pleased to announce the recent selection of the H2020 iPSpine project by the European commission. iPSpine will receive an overall grant of 15 M€. This large European consortium will gather 20 international partners and will be coordinated by Marianna Tryfonidou (Utrecht University, The Netherlands). This project will officially be launched in February 2019 and it will deal with the development of advanced therapy medicinal products based on the use of biomaterials and induced-pluripotent stem cells (iPSC) towards solving intervertebral disc (IVD) degeneration. Jerome Guicheux is the scientific coordinator of iPSpine workpackage (WP) 1 “iPSC development, differentiation and technologies” that gathers 7 international partners and focus on discovering innovative culture protocols for the generation of IVD cells derived from human iPSC (Anne Camus). In collaboration with the ONIRIS-national veterinary school of Nantes, the STEP team will also participate in WPs 3 and 6 respectively dedicated to (i) in vitro 3D cell culture (Catherine Le Visage, RMeS) and (ii) the first canine clinical trial related to the efficacy of the intradiscal injection of iPSC-derived regenerative cells in the treatment of low back pain (Marion Fusellier & Johann Clouet). RMeS will receive a global support of about 1.3 million Euros and will recruit 1 post-doc, 2 research assistants and 1 clinical assistant.

Workshops & symposia

4ème journée sur l'innovation technologique : "De la nanobiologie aux nanotechnologies", 24 janvier (Nantes)

Les ITMO "Physiopathologie, métabolisme, nutrition" et "Technologie pour la Santé" organisent la 4ème journée sur l'innovation technologique : "De la nanobiologie aux nanotechnologies". Cette journée est organisée à Paris mais avec retransmission vidéo dans 11 villes dont Nantes. J. Guicheux et J. Le Pendu animeront cette journée sur le site nantais.
RV dans la salle de réunion de l'unité RMeS le 24 janvier à partir de 9.00.



Guillaume MabilleauGuillaume Mabilleau, PhD

Gut hormones and bone quality

March 19th, 2019, 11h00 - Amphi Ricordeau (Dental Faculty)


Laurent DavidLaurent David, PhD

Hydrogels physiques de chitosane pour l'ingénierie tissulaire in vivo et in vitro

University Claude Bernard Lyon
November 26th, 2018, 14h30 - Amphi Ricordeau (Dental Faculty)


New members

Cassandra LepetitCassandra Lepetit

Cassandra is a M2 student.
She will work on the resolution of inflammation in clinical situations

She joined our unit on Jan. 7th 2019
Her supervisor is Alexis Gaudin

Edouard SamarutEdouard Samarut

Edouard is a M2 student.
He will work on REMEDIV & BIO2/STIMUDISC projects

He joined our unit on Jan. 7th 2019
His supervisor is Johann Clouet

Nathan LagneauNathan Lagneau

Nathan is a M2 student.
He will work on Shelby project

He joined our unit on Jan. 7th 2019
His supervisor is Vianney Delplace

Mélanie LefebvreMélanie Lefebvre

Mélanie is a M2 student.
She will work on Shelby project

She joined our unit on Jan. 7th 2019
Her supervisor is Vianney Delplace

Pierre KeribinPierre Keribin

Pierre is a M2 student.
He will work on IL-36γ molecule

He joined our unit on Jan. 7th 2019
His supervisors are Alexandra Cloitre & Philippe Lesclous

PhD defense & HDR

Maude GluaisPhD Defense of Maude Gluais

Maude Gluais defended her thesis on December 18, 2018, at 14.00 pm

Mise au point et évaluation de biomatériaux électrospinés pour la régénération de l’Annulus fibrosus

Directeur de thèse: C. Le Visage- Co-directeurs : J. Guicheux/J. Clouet. Congratulations Maude !

Amadou TourePhD Defense of Amadou Toure

Amadou Toure defended his thesis on December 19, 2018, at 9.30 am

Contribution au développement de substituts osseux auto-réticulants en ingénierie tissulaire osseuse maxillo-faciale

Directeur de thèse: P. Weiss - Co-directeur : B. Giumelli. Congratulations Amadou !

Alexandra CloitrePhD Defense of Alexandra Cloitre

Alexandra Cloitre defended her thesis on December 19, 2018, at 1.30 pm

La destruction osseuse parodontale : physiopathogénie et rôle des nouvelles interleukines

Directeur de thèse: P. Lesclous - Co-directeur : V. Geoffroy. Congratulations Alexandra !

And among other things...

General Assembly 2018
RMeS General Assemby (Campus Gavy - St Nazaire) -
May 14th, 2018

Photo Fête de Noël
Christmas Party RMeS ! December 18th, 2017

Olympiades RMES

The 2nd Edition of the RMeS "Olympiades" has taken place on Sept. 18th, 2017. 4 teams have met in good spirits. Thanks to all the participants!